Chemistry:Clidinium bromide
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| AHFS/Drugs.com | Monograph |
| MedlinePlus | a601036 |
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| Routes of administration | Oral |
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| Pharmacokinetic data | |
| Bioavailability | Low |
| Excretion | Renal and biliary |
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| Chemical and physical data | |
| Formula | C22H26NO3+ |
| Molar mass | 352.454 g·mol−1 |
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Clidinium bromide (INN) is an anticholinergic (specifically a muscarinic antagonist) drug.[1][2] It may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines. It is commonly prescribed in combination with chlordiazepoxide (a benzodiazepine derivative) using the brand name Normaxin.
Uses
Peptic ulcer disease
Used in fixed combination with chlordiazepoxide as adjunctive therapy in the treatment of peptic ulcer disease; however, no conclusive data that antimuscarinics aid in the healing, decrease the rate of recurrence, or prevent complications of peptic ulcers.[3]
With the advent of more effective therapies for the treatment of peptic ulcer disease, antimuscarinics have only limited usefulness in this condition.
GI motility disturbances
Used in fixed combination with chlordiazepoxide in the treatment of functional GI motility disturbances (e.g., irritable bowel syndrome).
Has limited efficacy in treatment of GI motility disturbance and should only be used if other measures (e.g., diet, sedation, counseling, amelioration of environmental factors) have been of little or no benefit.
Acute enterocolitis
Used in fixed combination with chlordiazepoxide in the treatment of acute enterocolitis. However, antimuscarinics should be used with extreme caution in patients with diarrhea or ulcerative colitis.
Mechanism of action
Clidinium inhibits muscarinic acetylcholine receptors on smooth muscles, secretory glands, and in the central nervous system to relax smooth muscle and decrease biliary tract secretions.[4]
References
- ↑ "Clidinium bromide". Drugs.com. https://www.drugs.com/international/clidinium-bromide.html.
- ↑ "Clidinium bromide". Meyler's side effects of drugs: the international encyclopedia of adverse drug reactions and interactions (Sixteenth ed.). Amsterdam: Elsevier. 2016. p. 404. ISBN 978-0-444-53716-4. https://books.google.com/books?id=NOKoBAAAQBAJ&pg=RA1-PA404&dq=Clidinium+bromide.
- ↑ "Clidinium Bromide Monograph". Drugs.com. https://www.drugs.com/monograph/clidinium-bromide.html.
- ↑ "Clidinium bromide". 2014 Nurse's Drug Handbook (13th ed.). Burlington, MA: Jones & Bartlett Learning. 2013. pp. 245–246. ISBN 978-1-284-03115-7. https://books.google.com/books?id=vJjv0U6o8YEC&dq=Clidinium&pg=PA245.
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