Chemistry:Digoxin

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Short description: Plant-derived medication
Digoxin
Digoxin.svg
Digon ball-and-stick.png
Clinical data
Pronunciation/dɪˈdʒɒksɪn/[1][2]
Trade namesLanoxin, others
AHFS/Drugs.comMonograph
MedlinePlusa682301
License data
Pregnancy
category
Routes of
administration		By mouth, intravenous
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
Bioavailability60 to 80% (by mouth)
Protein binding25%
MetabolismLiver (16%)
Elimination half-life36 to 48 hours
(normal kidney function)
3.5 to 5 days
(impaired kidney function)
ExcretionKidney
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
Chemical and physical data
FormulaC41H64O14
Molar mass780.949 g·mol−1
3D model (JSmol)
Melting point249.3 °C (480.7 °F)
Solubility in water0.0648 mg/mL (20 °C)
  (verify)

Digoxin (better known as Digitalis), sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions.[4] Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure.[4] Digoxin is one of the oldest medications used in the field of cardiology. It works by increasing myocardial contractility, increasing stroke volume and blood pressure, reducing heart rate, and somewhat extending the time frame of the contraction.[5] Digoxin is taken by mouth or by injection into a vein.[4] Digoxin has a half life of approximately 36 hours given at average doses in patients with normal renal function. It is excreted mostly unchanged in the urine.

Common side effects include breast enlargement with other side effects generally due to an excessive dose.[4][6] These side effects may include loss of appetite, nausea, trouble seeing, confusion, and an irregular heartbeat.[6] Greater care is required in older people and those with poor kidney function.[6] It is unclear whether use during pregnancy is safe.[3]

Digoxin is in the cardiac glycoside family of medications.[4] It was first isolated in 1930 from the foxglove plant, Digitalis lanata.[7][8] It is on the World Health Organization's List of Essential Medicines.[9] In 2021, it was the 241st most commonly prescribed medication in the United States, with more than 1 million prescriptions.[10][11]

Medical uses

Irregular heartbeat

The most common indications for digoxin are atrial fibrillation and atrial flutter with rapid ventricular response,[12][13] especially in older or less active patients,[14] though beta blockers and/or calcium channel blockers may be preferred in some patients, such as younger more active ones, or those without heart failure or hemodynamic instability.[15]

Early observational studies showed an increased risk of death in patients taking digoxin, despite an attempt to allow for other risk factors for death (so-called propensity score matching).[16][17] However, systematic reviews focusing on randomised controlled trials of digoxin (which ensured similarity between patients on digoxin, and those not on it) showed no difference in mortality.[18][19] Evidence suggested the increased mortality in patients taking digoxin was due to their having worse heart disease than those not taking it.[20] Cardiac arrhythmias may also occur when patients are prescribed digoxin alongside thiazides and loop diuretics.[21]

Heart failure

Digitalis (i.e. extracts, including digoxin, from the plant genus digitalis) was the first drug used to treat dropsy (swollen ankles—a symptom of heart failure) following its discovery by William Withering.[22] Alongside diuretics, it was the mainstay of treatment for heart failure for over a century. Since the introduction of other drugs with better outcomes and fewer adverse effects, it is generally now only used where heart failure is associated with atrial fibrillation and or a rapid ventricular rate.[23] In certain circumstances it may be used under specialist guidance in addition to, or instead of, the recommended first-line treatments of ACE inhibitor, beta blocker, mineralocorticoid antagonist, and SGLT-2 inhibitor, where they are not effective or not tolerated. [24][23]

Abortion

Digoxin is also used intrafetally or amniotically during abortions in the late second trimester and third trimester of pregnancy. It typically causes fetal demise (measured by cessation of cardiac activity) within hours of administration.[25]

Side effects

Main page: Chemistry:List of side effects of digoxin
Further information: Digoxin toxicity

The occurrence of adverse drug reactions is common, owing to its narrow therapeutic index (the margin between effectiveness and toxicity). Gynaecomastia (enlargement of breast tissue) is mentioned in many textbooks as a side effect, thought to be due to the estrogen-like steroid moiety of the digoxin molecule,[26] but when systematically sought, the evidence for this is equivocal (As of 2005).[27] The combination of increased (atrial) arrhythmogenesis and inhibited atrioventricular (AV) conduction (for example paroxysmal atrial tachycardia with AV block – so-called "PAT with block") is said to be pathognomonic (that is, diagnostic) of digoxin toxicity.[28]

Digoxin can lead to cardiac arrhythmias when given with thiazides and loop diuretics. This is because co-administration of Digoxin with drugs such as thiazides and loop diuretics which can cause hypokalemia, low serum levels of potassium in the blood. This exacerbates the potential for cardiac arrythmias because the low levels of potassium reduces the amount of K+ at the ATPase pump and increase calcium levels too much which leads to these arrythmias.[29] It can also cause visual disturbances as well as dizziness or fainting.

Several other drugs associated with ADRs in concommitant use include verapamil, amiodarone, quinidine, tetracycline, and erythromycin.

Overdose

In overdose, the usual supportive measures are needed. If arrhythmias prove troublesome, or malignant hyperkalemia occurs (inexorably rising potassium level due to paralysis of the cell membrane-bound, ATPase-dependent Na/K pumps), the specific antidote is antidigoxin (antibody fragments against digoxin, trade names Digibind and Digifab).[30] The mechanism of action for drugs such as Digibind and Digifab, used when adverse events occur with the use of digoxin, is that the FAB regions on the antibodies created against digoxin expedite the excretion of the drug into urine. Therefore, the amount of digoxin in the body decreases quickly as it gets excreted rapidly.

Pharmacology

Pharmacodynamics

Signal-averaged ECG from a person taking digoxin, explaining ST depressions in mainly precordial leads V4 and V5

Digoxin's primary mechanism of action involves inhibition of the sodium potassium adenosine triphosphatase (Na+/K+ ATPase), mainly in the myocardium.[5] This inhibition causes an increase in intracellular sodium levels, resulting in decreased activity of the sodium-calcium exchanger, which normally imports three extracellular sodium ions into the cell and transports one intracellular calcium ion out of the cell. The reversal of this exchanger, triggered by the increase in intracellular sodium, results in an increase in the intracellular calcium concentration that is available to the contractile proteins. The increased calcium concentrations lead to the binding of more calcium to troponin C, which results in increased inotropy. Increased intracellular calcium lengthens phase 4 and phase 0 of the cardiac action potential, which leads to a decrease in heart rate.[31] Increased amounts of Ca2+ also leads to increased storage of calcium in the sarcoplasmic reticulum, causing a corresponding increase in the release of calcium during each action potential. This leads to increased contractility (the force of contraction) of the heart without increasing heart energy expenditure.[citation needed]

The inhibition of the sodium pump may also improve baroreceptor sensitivity in heart failure and may explain some of the neurohormonal effects of digoxin.[32]

Digoxin also has important parasympathetic effects, particularly on the atrioventricular node.[33] While it does increase the magnitude of myocardial contractility, the duration of the contraction is only slightly increased. Its use as an antiarrhythmic drug, then, comes from its direct and indirect parasympathetic stimulating properties. Vagus nerve stimulation slows down conduction at the AV node by increasing the refractory period of cardiac myocytes. The slowed AV node gives the ventricles more time to fill before contracting. This negative chronotropic effect is synergistic with the direct effect on cardiac pacemaker cells. The arrhythmia itself is not affected, but the pumping function of the heart improves, owing to improved filling.

Overall, the heart rate is decreased while stroke volume is increased, resulting in a net increase in blood pressure, leading to increased tissue perfusion. This causes the myocardium to work more efficiently, with optimized hemodynamics and an improved ventricular function curve.

Other electrical effects include a brief initial increase in action potential, followed by a decrease as the K+ conductance increases due to increased intracellular amounts of Ca2+ ions. The refractory period of the atria and ventricles is decreased, while it increases in the sinoatrial and AV nodes. A less negative resting membrane potential is made, leading to increased irritability.

The conduction velocity increases in the atria, but decreases in the AV node. The effect upon Purkinje fibers and ventricles is negligible. Automaticity is also increased in the atria, AV node, Purkinje fibers, and ventricles.[34]

ECG changes seen in people taking digoxin include increased PR interval (due to decreased AV conduction) and a shortened QT interval. Also, the T wave may be inverted and accompanied by ST depression. It may cause AV junctional rhythm and ectopic beats (bigeminy) resulting in ventricular tachycardia and fibrillation.

Digoxin is also an M2 receptor muscarinic agonist.[35]

Pharmacokinetics

Digoxin is usually given orally, but can also be given by IV injection in urgent situations (the IV injection should be slow, and heart rhythm should be monitored). While IV therapy may be better tolerated (less nausea), digoxin has a very long distribution half-life into the cardiac tissue, which will delay its onset of action by a number of hours. The half-life is about 36 hours for patients with normal renal function, digoxin is given once daily, usually in 125 μg or 250 μg doses.[citation needed]

Digoxin elimination is mainly by renal excretion and involves P-glycoprotein, which leads to significant clinical interactions with P-glycoprotein inhibitor drugs. Examples commonly used in patients with heart problems include spironolactone, verapamil and amiodarone. In patients with decreased kidney function the half-life is considerably longer, along with decrease in Vd (volume of distribution), calling for a reduction in dose or a switch to a different glycoside, such as digitoxin (not available in the United States), which has a much longer elimination half-life of around seven days and is eliminated by the liver.[citation needed]

Effective plasma levels vary depending on the medical indication. For congestive heart failure, levels between 0.5 and 1.0 ng/mL are recommended.[36] This recommendation is based on post hoc analysis of prospective trials, suggesting higher levels may be associated with increased mortality rates. For heart rate control (atrial fibrillation), plasma levels are less defined and are generally titrated to a goal heart rate. Typically, digoxin levels are considered therapeutic for heart rate control between 0.5 and 2.0 ng/mL (or 0.6 and 2.6 nmol/L).[37] In suspected toxicity or ineffectiveness, digoxin levels should be monitored. Plasma potassium levels also need to be closely controlled (see side effects, below).

Quinidine, verapamil, and amiodarone increase plasma levels of digoxin (by displacing tissue binding sites and depressing renal digoxin clearance), so plasma digoxin must be monitored carefully when coadministered. [citation needed]

A study which looked to see if digoxin affected men and women differently found that digoxin did not reduce deaths overall, but did result in less hospitalization. Women who took digoxin died "more frequently" (33%) than women who took placebo (29%). Digoxin increased the risk of death in women by 23%. There was no difference in the death rate for men in the study.[38]

Digoxin is also used as a standard control substance to test for P-glycoprotein inhibition.[39]

Digoxin appears to be a peripherally selective drug due to limited brain uptake caused by binding to P-glycoprotein.[40][41]

Pharmacomicrobiomics

The bacteria Eggerthella lenta has been linked to a decrease in the toxicity of Digoxin.[42] These effects have been studied through comparisons of North Americans and Southern Indians, in which a reduced digoxin metabolite profile correlates with E. lenta abundance.[43] Further studies have also revealed an increase in digoxin toxicity when used alongside erythromycin or tetracycline, the researches attributed this to the decrease in the E. lenta population.[44]

History

Derivatives of plants of the genus Digitalis have a long history of medical use. Nicholas Culpeper referred to various medical uses for Foxglove in his 1652 publication The English physician.[45] William Withering is credited with the first published description of the systematic use of Digitalis derivatives in his 1785 book An Account of the Foxglove and some of its Medical Uses With Practical Remarks on Dropsy and Other Diseases.[46] Its use was somewhat sporadic until Sir James Mackenzie identified the phenomenon of atrial fibrillation, and the actions of digitalis on this.[47] Its effects were first explained by Arthur Robertson Cushny.[48] The name is a portmanteau, derived from Digitalis lanata and toxin.[49]

In 1930, Digoxin was first isolated by Dr. Sydney Smith from the foxglove plant, Digitalis lanata.[7][8][50] Initially, the digoxin was purified by dissolving the dried plant material in acetone and boiling the solution in chloroform. The solution was then reacted with acetic acid and small amount of ferric chloride and sulfuric acid (Keller reaction). Digoxin was distinguishable from other glucosides by the olive-green colored solution produced from this reaction, completely free of red.[50]

Society and culture

Charles Cullen admitted in 2003 to killing as many as 40 hospital patients with overdoses of heart medication—usually digoxin—at hospitals in New Jersey and Pennsylvania over his 19-year career as a nurse. On March 10, 2006, he was sentenced to 18 consecutive life sentences and is not eligible for parole.[51]

On April 25, 2008, the U.S. Food and Drug Administration (FDA) issued a press release[52] alerting the public to a Class I recall of Digitek, a brand of digoxin produced by Mylan.[53] Some tablets had been released at double thickness and therefore double strength, causing some patients to experience digoxin toxicity. A class-action lawsuit against the Icelandic generic drug maker Actavis was announced two weeks later.[54]

On March 31, 2009, the FDA announced another generic digoxin pill recall by posting this company press release on the agency's web site: "Caraco Pharmaceutical Laboratories, Ltd. Announces a Nationwide Voluntary Recall of All Lots of Digoxin Tablets Due to Size Variability". A March 31 press release from Caraco, a generic pharmaceutical company, stated:


A 2008 study suggested digoxin has beneficial effects not only for the heart, but also in reducing the risk of certain kinds of cancer.[55] However, comments on this study suggested that digoxin is not effective at reducing cancer risk at therapeutic concentrations of the drug,[56] so the results need further investigation.[57]

Brand names

Digoxin preparations are marketed under the brand names Cardigox; Cardiogoxin; Cardioxin; Cardoxin; Coragoxine; Digacin; Digicor; Digitek; Digomal; Digon; Digosin; Digoxine Navtivelle; Digoxina-Sandoz; Digoxin-Sandoz; Digoxin-Zori; Dilanacin; Eudigox; Fargoxin; Grexin; Lanacordin; Lanacrist; Lanicor; Lanikor; Lanorale; Lanoxicaps; Lanoxin; Lanoxin PG; Lenoxicaps; Lenoxin; Lifusin; Mapluxin; Natigoxin; Novodigal; Purgoxin; Sigmaxin; Sigmaxin-PG; Toloxin.[58][59]

Digoxin and cancer

Cardiac glycosides, particularly digoxin, have been conventionally used for treatment of common cardiac problems, mainly heart failure and cardiac arrhythmias. The interaction of digoxin and cancer has also been studied. Despite existence of numerous preclinical studies that investigated the anticancer effects of digoxin, there are no solid and conclusive results so far.

Several studies have suggested that digoxin may have anticancer properties,[60] others not.[61]

Digoxin, as a cardiac glycoside, has a chemical structure basically similar to that of estradiol. Digoxin has the ability to bind oestrogen receptors, and therefore it has been proposed that it might increase the risk of oestrogen-sensitive breast and uterine cancers.[62] A large Danish study found a complicated picture, with slightly increased risk of breast cancer amongst women taking digoxin, but better prognostic features.[63] The Nurses' Health Study found a similar slight increase of risk.[64]

Digoxin inhibits the proliferation of many cancerous cell lines in vitro,[65][66] but its relevance to cancer in vivo remains unclear.

References

  1. ↑ "Digoxin | Definition of Digoxin by Lexico" (in en). Digoxin | Definition of Digoxin by Lexico. 
  2. ↑ "digoxin". https://www.wordreference.com/definition/digoxin. 
  3. ↑ 3.0 3.1 "Digoxin Use During Pregnancy". https://www.drugs.com/pregnancy/digoxin.html. 
  4. ↑ 4.0 4.1 4.2 4.3 4.4 "Digoxin". The American Society of Health-System Pharmacists. https://www.drugs.com/monograph/digoxin.html. 
  5. ↑ 5.0 5.1 "Digoxin: Pharmacology and toxicology-A review". Environmental Toxicology and Pharmacology 79: 103400. October 2020. doi:10.1016/j.etap.2020.103400. PMID 32464466. https://www.sciencedirect.com/science/article/pii/S1382668920300764. 
  6. ↑ 6.0 6.1 6.2 WHO Model Formulary 2008. World Health Organization. 2009. p. 270. ISBN 9789241547659. 
  7. ↑ 7.0 7.1 (in en) The British Pharmacopoeia, 1864 to 2014: Medicines, International Standards and the State. Routledge. 2016. p. 183. ISBN 9781317039792. https://books.google.com/books?id=gI21CwAAQBAJ&pg=PA183. 
  8. ↑ 8.0 8.1 "Drugs for atrial fibrillation. Digoxin comes from Digitalis lanata". BMJ 312 (7035): 912. April 1996. doi:10.1136/bmj.312.7035.912. PMID 8611904. 
  9. ↑ World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO. 
  10. ↑ "The Top 300 of 2021". https://clincalc.com/DrugStats/Top300Drugs.aspx. 
  11. ↑ "Digoxin - Drug Usage Statistics". https://clincalc.com/DrugStats/Drugs/Digoxin. 
  12. ↑ "Effects of digoxin on acute, atrial fibrillation-induced changes in atrial refractoriness". Circulation 102 (20): 2503–8. November 2000. doi:10.1161/01.CIR.102.20.2503. PMID 11076824. 
  13. ↑ "Digoxin and mortality in atrial fibrillation: a prospective cohort study". European Journal of Clinical Pharmacology 63 (10): 959–71. October 2007. doi:10.1007/s00228-007-0346-9. PMID 17684738. 
  14. ↑ Kumar and clark's clinical medicine (9th ed.). Edinburgh London New York Oxford Philadelphia St Louis Sydney Toronto: Elsevier. 2017. p. 972. ISBN 9780702066009. 
  15. ↑ "2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society in Collaboration With the Society of Thoracic Surgeons". Circulation 140 (2): e125–e151. July 2019. doi:10.1161/CIR.0000000000000665. PMID 30686041. 
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  20. ↑ "Safety and efficacy of digoxin: systematic review and meta-analysis of observational and controlled trial data". BMJ 351: h4451. August 2015. doi:10.1136/bmj.h4451. PMID 26321114. 
  21. ↑ Kumar and Clark's clinical medicine (9th ed.). Edinburgh London New York Oxford Philadelphia St Louis Sydney Toronto: Elsevier. 2017. p. 24. ISBN 9780702066009. 
  22. ↑ An Account of the Foxglove and some of its Medical Uses. Birmingham, England: M. Swinney. 1785. https://archive.org/details/b21517356. 
  23. ↑ 23.0 23.1 "2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure". European Heart Journal (European Society of Cardiology) 42 (36): 3599–3726. September 2021. doi:10.1093/eurheartj/ehab368. PMID 34447992. 
  24. ↑ "2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure". The Canadian Journal of Cardiology 33 (11): 1342–1433. November 2017. doi:10.1016/j.cjca.2017.08.022. PMID 29111106. 
  25. ↑ Management of Unintended and Abnormal Pregnancy: Comprehensive Abortion Care. John Wiley & Sons. 2011-08-24. ISBN 9781444358476. https://books.google.com/books?id=iK7xrRr2p9sC. 
  26. ↑ "Repercussions of digoxin, digitoxin and estradiol on the endometrial histomorphometry of oophorectomized mice". Gynecological Endocrinology 20 (4): 213–20. April 2005. doi:10.1080/09513590400021219. PMID 16019364. 
  27. ↑ "Drug-induced gynecomastia". Pharmacotherapy 13 (1): 37–45. 1993. doi:10.1002/j.1875-9114.1993.tb02688.x. PMID 8094898. 
  28. ↑ "[Digitalis intoxication: specifity and significance of cardiac and extracardiac symptoms. part I: Patients with digitalis-induced arrhythmias (author's transl)]" (in de). Zeitschrift für Kardiologie 66 (3): 121–8. March 1977. PMID 857452. 
  29. ↑ A Textbook of Clinical Pharmacology and Therapeutics (5th ed.). London: Hodder Arnold. 2008. p. 75. ISBN 978-0-340-90046-8. 
  30. ↑ "Fab antibody fragments: some applications in clinical toxicology". Drug Safety 27 (14): 1115–33. 2004. doi:10.2165/00002018-200427140-00004. PMID 15554746. http://drugsafety.adisonline.com/pt/re/drs/fulltext.00002018-200427140-00004.htm. Retrieved July 16, 2007. 
  31. ↑ Tripathi, K. D., ed (2008-12-01). Essentials of Medical Pharmacology (6th ed.). New Delhi: Jaypee Publications. pp. 498. ISBN 978-81-8448-085-6. 
  32. ↑ "Carotid sinus baroreceptor sensitivity in experimental heart failure". Circulation 81 (6): 1959–66. June 1990. doi:10.1161/01.cir.81.6.1959. PMID 2344687. 
  33. ↑ "Digoxin in the management of cardiovascular disorders". Circulation 109 (24): 2959–64. June 2004. doi:10.1161/01.cir.0000132482.95686.87. PMID 15210613. 
  34. ↑ Cardiology Secrets. Elsevier. 2018. pp. 241–252. ISBN 978-0-323-47870-0. https://www.sciencedirect.com/book/9780323478700/cardiology-secrets. Retrieved 2021-03-28. 
  35. ↑ "Antiarrhythmic Medications". StatPearls. Treasure Island (FL): StatPearls Publishing. 2023. https://www.ncbi.nlm.nih.gov/books/NBK482322/. Retrieved 7 May 2023. 
  36. ↑ "ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society". Circulation 112 (12): e154-235. September 2005. doi:10.1161/CIRCULATIONAHA.105.167586. PMID 16160202. 
  37. ↑ "Digoxin and Therapeutic Cardiac Glycosides". Medical Toxicology. Lippincott Williams & Wilkins. 2004. p. 700. ISBN 978-0-7817-2845-4. https://books.google.com/books?id=BfdighlyGiwC&pg=PA700. Retrieved 2016-12-15. ()
  38. ↑ "Sex-based differences in the effect of digoxin for the treatment of heart failure". The New England Journal of Medicine 347 (18): 1403–11. October 2002. doi:10.1056/NEJMoa021266. PMID 12409542. 
  39. ↑ "Membrane transporters in drug development". Nature Reviews. Drug Discovery 9 (3): 215–236. March 2010. doi:10.1038/nrd3028. PMID 20190787. 
  40. ↑ "P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs". Int J Clin Pharmacol Ther 38 (2): 69–74. February 2000. doi:10.5414/cpp38069. PMID 10706193. 
  41. ↑ "P-Glycoprotein, a gatekeeper in the blood-brain barrier". Adv Drug Deliv Rev 36 (2–3): 179–194. April 1999. doi:10.1016/s0169-409x(98)00085-4. PMID 10837715. 
  42. ↑ "PharmacoMicrobiomics". http://pharmacomicrobiomics.com/select/?q=2. 
  43. ↑ "Geographic differences in digoxin inactivation, a metabolic activity of the human anaerobic gut flora". Gut 30 (7): 971–7. July 1989. doi:10.1136/gut.30.7.971. PMID 2759492. 
  44. ↑ "Inactivation of digoxin by the gut flora: reversal by antibiotic therapy". The New England Journal of Medicine 305 (14): 789–94. October 1981. doi:10.1056/NEJM198110013051403. PMID 7266632. 
  45. ↑ (in en) The English Physician, Etc (1st ed.). London: William Bentley. 1652. pp. 97–98. https://books.google.com/books?id=WuyUw_5Hd8cC&pg=RA1-PA173. Retrieved 22 January 2023. 
  46. ↑ An Account of the Foxglove and some of its Medical Uses With Practical Remarks on Dropsy and Other Diseases. 1785. http://www.gutenberg.org/ebooks/24886. 
  47. ↑ An Account of the Foxglove and its Medical Uses 1785–1985 (1st ed.). London: Oxford University Press. 1985. pp. Chapters 5–7. ISBN 0192615017. 
  48. ↑ "The Action and Uses in Medicine of Digitalis and its Allies" (in en). Nature (London: Longmans, Green and Co) 116 (2905): 8–9. 1925. doi:10.1038/116008a0. Bibcode: 1925Natur.116....8.. https://www.nature.com/articles/116008a0. 
  49. ↑ "digoxin" (in en). Wikimedia. 16 January 2023. https://en.wiktionary.org/wiki/digoxin. 
  50. ↑ 50.0 50.1 "LXXII.—Digoxin, a new digitalis glucoside". J. Chem. Soc. (The Royal Society of Chemistry): 508–510. 1930. doi:10.1039/JR9300000508. https://pubs.rsc.org/en/content/articlepdf/1930/jr/jr9300000508. Retrieved 2020-10-22. 
  51. ↑ "Victims' families set to confront killer". USA Today. 2006-01-01. http://usatoday.com/news/nation/2006-01-01-patient-deaths_x.htm. 
  52. ↑ "Recalls, Market Withdrawals & Safety Alerts". Federal Drugs Administration. 2008-10-15. https://www.fda.gov/oc/po/firmrecalls/actavis04_08.html. 
  53. ↑ "Urgent Digitek Digoxin Recall". U.S. Recall News. 2008-04-28. http://www.usrecallnews.com/2008/04/urgent-digitek-digoxin-recall.html. 
  54. ↑ "Patients Sue Icelandic Drugmaker Over Recalled Heart Drug". The Wall Street Journal. 2008-05-09. https://blogs.wsj.com/health/2008/05/09/patients-sue-icelandic-drugmaker-over-recalled-heart-drug/. 
  55. ↑ "Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth". Proceedings of the National Academy of Sciences of the United States of America 105 (50): 19579–86. December 2008. doi:10.1073/pnas.0809763105. PMID 19020076. Bibcode: 2008PNAS..10519579Z. 
  56. ↑ "Digoxin, HIF-1, and cancer". Proceedings of the National Academy of Sciences of the United States of America 106 (9): E26; author reply E27. March 2009. doi:10.1073/pnas.0813047106. PMID 19240208. Bibcode: 2009PNAS..106E..26L. 
  57. ↑ "AIDS and the nervous system: current status and future perspectives". Human Pathology 20 (5): 410–8. May 1989. doi:10.1016/0046-8177(89)90004-x. PMID 2651280. 
  58. ↑ "Digoxin: a medicine to treat heart problems" (in en). 2021-09-15. https://www.nhs.uk/medicines/digoxin/. 
  59. ↑ "Digoxin Tablets: Uses & Side Effects" (in en). https://my.clevelandclinic.org/health/drugs/19363-digoxin-tablets. 
  60. ↑ "Integrative analysis of clinical and bioinformatics databases to identify anticancer properties of digoxin". Scientific Reports 9 (1): 16597. November 2019. doi:10.1038/s41598-019-53392-y. PMID 31719612. Bibcode: 2019NatSR...916597Y. 
  61. ↑ "Digoxin and prostate cancer survival in the Finnish Randomized Study of Screening for Prostate Cancer". British Journal of Cancer 115 (11): 1289–1295. November 2016. doi:10.1038/bjc.2016.328. PMID 27755533. 
  62. ↑ "Digoxin use and the risk of breast cancer in women". Journal of Clinical Oncology 29 (16): 2165–70. June 2011. doi:10.1200/JCO.2010.32.8146. PMID 21422417. 
  63. ↑ "Breast cancer in women using digoxin: tumor characteristics and relapse risk". Breast Cancer Research 15 (1): R13. February 2013. doi:10.1186/bcr3386. PMID 23421975. 
  64. ↑ "Digoxin use and risk of invasive breast cancer: evidence from the Nurses' Health Study and meta-analysis". Breast Cancer Research and Treatment 144 (2): 427–35. April 2014. doi:10.1007/s10549-014-2886-x. PMID 24573543. 
  65. ↑ "Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer". Cancer Biology & Therapy 20 (1): 52–64. 2019-01-02. doi:10.1080/15384047.2018.1504723. PMID 30183476. 
  66. ↑ "Risk of cancer in patients with heart failure who use digoxin: a 10-year follow-up study and cell-based verification". Oncotarget 8 (27): 44203–44216. July 2017. doi:10.18632/oncotarget.17410. PMID 28496002. 

Further reading

  • Pharmacology (5th ed.). Edinburgh: Churchill Livingstone. 2003. ISBN 0-443-07145-4. 
  • Summary of Product Characteristics, Digoxin 0.125 mg, Zentiva.
  • Pharmakologie und Toxikologie (15th ed.). Georg Thieme Verlag. 2003. ISBN 3-13-368515-5. 
  • Lanatoside C (isolanid, Cedilanid – four glycoside analog), Digoxigenin (aglycone analog)
  • "Digitalis use in contemporary clinical practice: refitting the foxglove". JAMA Internal Medicine 174 (1): 151–154. January 2014. doi:10.1001/jamainternmed.2013.10432. PMID 24217624. 



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