Chemistry:Fedratinib
 | |
| Clinical data | |
|---|---|
| Trade names | Inrebic |
| Other names | SAR302503; TG101348 |
| AHFS/Drugs.com | Monograph |
| License data | |
| Routes of administration | By mouth |
| Drug class | Antineoplastic agent |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C27H36N6O3S |
| Molar mass | 524.68 g·mol−1 |
| 3D model (JSmol) | |
| Density | 1.247 ± 0.06 g/cm3 |
| |
| |
  (what is this?) | |
Fedratinib, sold under the brand name Inrebic, is an anti-cancer medication used to treat myeloproliferative diseases including myelofibrosis.[5] It is used in the form of fedratinib hydrochloride capsules that are taken by mouth. It is a semi-selective inhibitor of Janus kinase 2 (JAK-2).[5][6] It was approved by the FDA on 16 August 2019.[5]
Myelofibrosis is a myeloid cancer associated with anemia, splenomegaly, and constitutional symptoms. Patients with myelofibrosis frequently harbor mutations which activate the JAK-STAT signaling pathway and which are sensitive to fedratinib. Phase I trial results focused on safety and efficacy of fedratinib in patients with high- or intermediate-risk primary or post–polycythemia vera/essential thrombocythemia myelofibrosis have been published in 2011.[7]
Medical uses
In the United States, fedratinib is indicated for the treatment of adults with intermediate-2 or high-risk primary or secondary (following polycythemia vera or essential thrombocythemia) myelofibrosis.[2]
In the European Union, fedratinib is indicated for the treatment of disease-related splenomegaly or symptoms in adults with primary myelofibrosis, following polycythaemia vera or essential thrombocythaemia, who are Janus kinase (JAK) inhibitor naïve or have been treated with ruxolitinib.[3]
Pharmacology
Mechanism of action
Fedratinib acts as a competitive inhibitor of protein kinase JAK-2 with IC50=6 nM; related kinases FLT3 and RET are also sensitive, with IC50=25 nM and IC50=17 nM, respectively. Significantly less activity was observed against other tyrosine kinases including JAK3 (IC50=169 nM).[8] In treated cells the inhibitor blocks downstream cellular signalling (JAK-STAT) leading to suppression of proliferation and induction of apoptosis.
History
Fedratinib was originally discovered at TargeGen. In 2010, Sanofi-Aventis acquired TargeGen and continued development of fedratinib until 2013. In 2016, Impact Biomedicines acquired the rights to fedratinib from Sanofi and continued its development for the treatment of myelofibrosis and polycythemia vera. In January 2018, the drug's rights were transferred to Celgene with their purchase of Impact Biomedicines.[9]
Fedratinib was approved for medical use in the United States in August 2019.[2][5][6]
The U.S. Food and Drug Administration (FDA) granted the application for fedratinib priority review and orphan drug designations.[5] The FDA granted the approval of Inrebic to Impact Biomedicines, Inc., a wholly owned subsidiary of Celgene Corporation.[5]
References
- ↑ "Summary Basis of Decision (SBD) for Inrebic". 23 October 2014. https://hpr-rps.hres.ca/reg-content/summary-basis-decision-detailTwo.php?linkID=SBD00502&lang=en.
- ↑ 2.0 2.1 2.2 "Inrebic- fedratinib hydrochloride capsule". https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f0f55a2a-4e0c-4cba-8571-03e1424486d7.
- ↑ 3.0 3.1 "Inrebic EPAR". 9 December 2020. https://www.ema.europa.eu/en/medicines/human/EPAR/inrebic. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ↑ "Inrebic Product information". https://ec.europa.eu/health/documents/community-register/html/h1514.htm.
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 "FDA approves treatment for patients with rare bone marrow disorder". U.S. Food and Drug Administration (FDA) (Press release). 16 August 2019. Archived from the original on 21 November 2019. Retrieved 16 August 2019.
This article incorporates text from this source, which is in the public domain.
- ↑ 6.0 6.1 "Drug Trials Snapshots: Inrebic". 30 August 2019. https://www.fda.gov/drugs/resources-information-approved-drugs/drug-trials-snapshots-inrebic. This article incorporates text from this source, which is in the public domain.
- ↑ "Safety and efficacy of TG101348, a selective JAK2 inhibitor, in myelofibrosis". Journal of Clinical Oncology 29 (7): 789–796. March 2011. doi:10.1200/JCO.2010.32.8021. PMID 21220608.
- ↑ "TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations". Leukemia 21 (8): 1658–1668. August 2007. doi:10.1038/sj.leu.2404750. PMID 17541402.
- ↑ "Celgene to Acquire Impact Biomedicines, Adding Fedratinib to Its Pipeline of Novel Therapies for Hematologic Malignancies". Celgene (Press release). 7 January 2018. Archived from the original on 31 October 2021. Retrieved 2018-01-18.
External links
- "Fedratinib". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/fedratinib.
- Clinical trial number NCT01437787 for "Phase III Study of SAR302503 in Intermediate-2 and High Risk Patients With Myelofibrosis (JAKARTA)" at ClinicalTrials.gov
 |  |
