Chemistry:Corticotropin-like intermediate peptide

From HandWiki
pro-opiomelanocortin
Corticotropin-like intermediate peptide.svg
Identifiers
SymbolPOMC
NCBI gene5443
HGNC9201
OMIM176830
RefSeqNM_000939
UniProtP01189
Other data
LocusChr. 2 p23
Corticotropin-like intermediate peptide
Corticotropin-like intermediate peptide.svg
Names
IUPAC name
L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyl-L-asparaginyl-L-glycyl-L-alanyl-L-α-glutamyl-L-α-aspartyl-L-α-glutamyl-L-seryl-L-alanyl-L-α-glutamyl-L-alanyl-L-phenylalanyl-L-prolyl-L-leucyl-L-α-glutamyl-L-phenylalanine
Identifiers
3D model (JSmol)
ChemSpider
Properties
C112H165N27O36
Molar mass 2465.705 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Corticotropin-like intermediate [lobe] peptide (CLIP), also known as adrenocorticotropic hormone fragment 18-39 (ACTH(18-39)), is a naturally occurring, endogenous neuropeptide with a docosapeptide structure and the amino acid sequence Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe. CLIP is generated as a proteolyic cleavage product of adrenocorticotropic hormone (ACTH),[1][2] which in turn is a cleavage product of proopiomelanocortin (POMC).[3] Its physiological role has been investigated in various tissues,[4][5] specifically in the central nervous system.[6][7][8][9][10]

It has been suggested to function as an insulin secretagogue in the pancreas.[11]

References

  1. ↑ "Biosynthesis and characterization of adrenocorticotropic hormone, alpha-melanocyte-stimulating hormone, and an NH2-terminal fragment of the adrenocorticotropic hormone/beta-lipotropin precursor from rat pars intermedia". The Journal of Biological Chemistry 254 (23): 11903–6. December 1979. doi:10.1016/S0021-9258(19)86402-5. PMID 227883. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=227883. 
  2. ↑ Lloyd D. Fricker (24 July 1991). Peptide biosynthesis and processing. CRC Press. pp. 78. ISBN 978-0-8493-8852-1. https://books.google.com/books?id=cvvW1e3T__sC&pg=PA78. Retrieved 25 November 2011. 
  3. ↑ Anthony W. Norman; Gerald Litwack (26 September 1997). Hormones. Academic Press. pp. 12. ISBN 978-0-12-521441-4. https://archive.org/details/hormones00norm. Retrieved 25 November 2011. 
  4. ↑ "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation 74 (5): 1886–9. November 1984. doi:10.1172/JCI111608. PMID 6209301. 
  5. ↑ "Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain". Brain Research Bulletin 26 (1): 99–111. January 1991. doi:10.1016/0361-9230(91)90194-O. PMID 1849784. 
  6. ↑ Shojiro Inoué; Shojiro Inoué (1989). Biology of sleep substances. CRC Press. pp. 136. ISBN 978-0-8493-4822-8. https://books.google.com/books?id=rT7clpjUwaEC&pg=PA136. Retrieved 25 November 2011. 
  7. ↑ "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 1--Hypnogenic properties of ACTH derivatives". Neuropeptides 15 (2): 61–74. February 1990. doi:10.1016/0143-4179(90)90042-w. PMID 1981927. 
  8. ↑ "Proopiomelanocortin (POMC)-derived peptides and sleep in the rat. Part 2--Aminergic regulatory processes". Neuropeptides 15 (2): 75–88. February 1990. doi:10.1016/0143-4179(90)90043-x. PMID 1964203. 
  9. ↑ "Effect of corticotropin-like intermediate lobe peptide on presynaptic and postsynaptic glutamate receptors and postsynaptic GABA receptors in rat brain". Bulletin of Experimental Biology and Medicine 147 (3): 319–22. March 2009. doi:10.1007/s10517-009-0499-x. PMID 19529852. 
  10. ↑ "Neuronal transmission of hippocampal CA1 neurones is modulated by corticotropin-like intermediate lobe peptide [CLIP; ACTH(18-39)]". Peptides 14 (6): 1221–4. 1993. doi:10.1016/0196-9781(93)90179-K. PMID 8134304. 
  11. ↑ Marshall, J. B.; Kapcala, L. P.; Manning, L. D.; McCullough, A. J. (November 1984). "Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules". The Journal of Clinical Investigation 74 (5): 1886–1889. doi:10.1172/JCI111608. ISSN 0021-9738. PMID 6209301. 

External links




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