Chemistry:Oxyphenbutazone
From HandWiki
Short description: Chemical compound
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| Trade names | Tandearil, Tanderil |
| AHFS/Drugs.com | International Drug Names |
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| Formula | C19H20N2O3 |
| Molar mass | 324.380 g·mol−1 |
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| Chirality | Racemic mixture |
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Oxyphenbutazone is a nonsteroidal anti-inflammatory drug (NSAID).[1] It is a metabolite of phenylbutazone.[2]
It was withdrawn from markets worldwide in mid-1980s due to bone marrow suppression and the risk of Stevens–Johnson syndrome.[3][4]
Trivia
The word "oxyphenbutazone" is theoretically the highest-scoring Scrabble move known with 1,780 points, but playing the word would require extremely unlikely circumstances. (according to the TWL06 dictionary) [5]
References
- ↑ "Phospholipase A2 as a target protein for nonsteroidal anti-inflammatory drugs (NSAIDS): crystal structure of the complex formed between phospholipase A2 and oxyphenbutazone at 1.6 A resolution". Biochemistry 43 (46): 14577–83. November 2004. doi:10.1021/bi0483561. PMID 15544328.
- ↑ "Pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in miniature donkeys". American Journal of Veterinary Research 62 (5): 673–5. May 2001. doi:10.2460/ajvr.2001.62.673. PMID 11341383.
- ↑ "Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999". Therapeutic Innovation & Regulatory Science 35 (1): 293–317. January 2001. doi:10.1177/009286150103500134.
- ↑ "Withdrawal of oxyphenbutazone: what about phenylbutazone?". CMAJ 134 (10): 1119–20. May 1986. PMID 3697857.
- ↑ Wood, Dave (22 May 2008). "Record for the Highest Scoring Scrabble Move". Scrabulizer. https://www.scrabulizer.com/blog/post/3#blog_post_break.
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