Chemistry:Mavacoxib

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Short description: Veterinary drug
Mavacoxib
Mavacoxib.svg
Clinical data
Trade namesTrocoxil
AHFS/Drugs.comInternational Drug Names
ATCvet code
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
Chemical and physical data
FormulaC16H11F4N3O2S
Molar mass385.34 g·mol−1
3D model (JSmol)

Mavacoxib (trade name Trocoxil) is a veterinary drug used to treat pain and inflammation in dogs with degenerative joint disease.[1] It acts as a COX-2 inhibitor.[2]

Mavacoxib, along with other COX-2 selective inhibitors, celecoxib, valdecoxib, and parecoxib, were discovered by a team at the Searle division of Monsanto led by John Talley.[3][4]

References

  1. European Public Assessment Report (EPAR): Trocoxil, European Medicines Agency
  2. "The pharmacokinetics of mavacoxib, a long-acting COX-2 inhibitor, in young adult laboratory dogs". Journal of Veterinary Pharmacology and Therapeutics 33 (5): 461–70. October 2010. doi:10.1111/j.1365-2885.2010.01165.x. PMID 20840390. 
  3. Langreth, Robert (June 23, 2003). "The Chemical Cobbler". Forbes. https://www.forbes.com/global/2003/0623/050.html. 
  4. "Dr. John Talley: 2001 St. Louis Awardee". Chemical Bond (St. Louis Section, American Chemical Society) 52 (5): 2. May 2001. http://www.stlacs.org/Bonds/2001May.pdf.