Chemistry:Droxicam
From HandWiki
Droxicam is a non-steroidal anti-inflammatory drug of the oxicam class. A prodrug of piroxicam, it is used for the relief of pain and inflammation in musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.[1]
Synthesis
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When heated, phenyl pyridin-2-ylcarbamate (1) decomposes to 2-isocyanatopyridine (2) which reacts with the heterocyclic compound (3) to give droxicam.[2][3][4]
References
- ↑ "Droxicam: a pharmacological and clinical review of a new NSAID". European Journal of Rheumatology and Inflammation 11 (4): 3–9. 1991. PMID 1365488.
- ↑ Jose M. Ribalta-Baro and Jordi F. Rigola-Constansa, "Benzothiazine derivatives and their applications as medicinal products or as synthesis intermediates for medicinal products", US patent 4563452, issued 1992-07-21, assigned to Laboratorios del Dr Esteve SA
- ↑ "Droxicam". Thieme. https://pharmaceutical-substances.thieme.com/ps/search-results?docUri=KD-04-0164.
- ↑ "Droxicam". https://www.chemdrug.com/article/8/3284/16419975.html.
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