Chemistry:Fenclozic acid

Fenclozic acid
Identifiers
	IUPAC name [2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid;
CAS Number	17969-20-9 ;
PubChem CID	28858;
ChemSpider	26843 ;
UNII	58SRQ4DV53;
Chemical and physical data
Formula	C11H8ClNO2S
Molar mass	253.70 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1cc(ccc1c2nc(cs2)CC(=O)O)Cl;
	InChI InChI=1S/C11H8ClNO2S/c12-8-3-1-7(2-4-8)11-13-9(6-16-11)5-10(14)15/h1-4,6H,5H2,(H,14,15) ; Key:APBSKHYXXKHJFK-UHFFFAOYSA-N ;
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Short description: Chemical compound

Fenclozic acid is an analgesic, antipyretic, and anti-inflammatory drug.^[1] It has been withdrawn in 1970 due to jaundice.^[2]

References

↑ Hepworth W, Stacey GJ, "Aryl-thiazolyl-acetic acid derivatives", US patent 3538107, issued 1970, assigned to Imperial Chemical Industries Ltd
↑ "Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999". Therapeutic Innovation & Regulatory Science 35 (1): 293–317. 1 January 2001. doi:10.1177/009286150103500134.

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[1] Hepworth W, Stacey GJ, "Aryl-thiazolyl-acetic acid derivatives", US patent 3538107, issued 1970, assigned to Imperial Chemical Industries Ltd

[Fung-2001-2] "Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999". Therapeutic Innovation & Regulatory Science 35 (1): 293–317. 1 January 2001. doi:10.1177/009286150103500134.

[1]

[2]

v t e Nonsteroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
Pyrazolones / Pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
Salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
Acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bumadizone Bufexamac Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
Oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam
Propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
N-Arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Flufenamic acid Flunixin Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid Flutiazin
Coxibs	Apricoxib Celecoxib Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
Other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase/Orgotein Tenidap
Items listed in bold indicate initially developed compounds of specific groups. ^#WHO-EM ^†Withdrawn drugs. ^‡Veterinary use medications.

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Identifiers

IUPAC name [2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid
CAS Number	17969-20-9^Y
PubChem CID	28858
ChemSpider	26843^N
UNII	58SRQ4DV53
Chemical and physical data
Formula	C₁₁H₈ClNO₂S
Molar mass	253.70 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c1cc(ccc1c2nc(cs2)CC(=O)O)Cl
InChI InChI=1S/C11H8ClNO2S/c12-8-3-1-7(2-4-8)11-13-9(6-16-11)5-10(14)15/h1-4,6H,5H2,(H,14,15)^N Key:APBSKHYXXKHJFK-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

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