Chemistry:Vedaprofen
Vedaprofen is a nonsteroidal anti-inflammatory drug (NSAID) used in veterinary medicine for the treatment of pain and inflammation due to musculoskeletal disorders in dogs and horses and for the treatment of pain due to horse colic.[1] It is a member of the profen drug class.
Medical uses
Vedaprofen is indicated for the reduction of inflammation and relief of pain associated with musculo-skeletal disorders and soft tissue lesions (traumatic injuries and surgical trauma).[2][3]
Synthesis
Vedaprofen can be synthesized beginning with 1-cyclohexylnaphthylene (left).[4][5] Chloromethylation followed by functional group interconversion provides the ester (center right). Alkylation with methyl iodide then gives vedaprofen (right).
Society and culture
Legal status
Vedaprofen was approved for veterinary use in the European Union in April 1997.[2][3]
References
- ↑ "Specific Nonsteroidal Anti-inflammatory Drugs". Merck Veterinary Manual. Merck Sharp & Dohme Corp. http://www.merckvetmanual.com/mvm/index.jsp?cfile=htm/bc/191606.htm.
- ↑ 2.0 2.1 Cite error: Invalid
<ref>tag; no text was provided for refs namedQuadrisol EPAR - ↑ 3.0 3.1 Cite error: Invalid
<ref>tag; no text was provided for refs namedVedaprofen PI - ↑ BE patent 870553
- ↑ U.S. Patent 4,218,473
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