Chemistry:Tenidap
From HandWiki
Short description: Chemical compound
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| Formula | C14H9ClN2O3S |
| Molar mass | 320.75 g·mol−1 |
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Tenidap was a COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory drug candidate[1] that was under development by Pfizer as a promising potential treatment for rheumatoid arthritis,[2] but Pfizer halted development after marketing approval was rejected by the FDA in 1996[3] due to liver and kidney toxicity, which was attributed to metabolites of the drug with a thiophene moiety that caused oxidative damage.[4]
References
- ↑ "A comparative study of tenidap, a cytokine-modulating anti-rheumatic drug, and diclofenac in rheumatoid arthritis: a 24-week analysis of a 1-year clinical trial". British Journal of Rheumatology 34 (6): 554–63. June 1995. doi:10.1093/rheumatology/34.6.554. PMID 7543348.
- ↑ Staff, American Journal of Nursing. Drug Watch: Tenidap Offers Arthritis Therapy Minus Toxicity AJN 1996 96(1):58
- ↑ Pfizer. Sept 27, 1996 Press release: Pfizer To Halt Plans For Commercialization Of Tenidap For Rheumatoid Arthritis
- ↑ "Rationally designed multitarget agents against inflammation and pain". Current Medicinal Chemistry 20 (13): 1783–99. 2013. doi:10.2174/0929867311320130013. PMID 23410172.
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