Biology:Firocoxib

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Short description: COX-2 selective NSAID veterinary drug
Firocoxib
Firocoxib.svg
Firocoxib molecule
Clinical data
Trade namesEquioxx, Previcox
AHFS/Drugs.comVeterinary Use
Veterinary Use
License data
Routes of
administration
By mouth
ATCvet code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC17H20O5S
Molar mass336.40 g·mol−1
3D model (JSmol)
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Firocoxib, sold under the brand names Equioxx and Previcox among others, is a nonsteroidal anti-inflammatory drug of the COX-2 inhibitor (coxib) class, approved for use in horses (Equioxx) and for use in dogs (Previcox).[1][3][6] Firocoxib was the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses.[7] Firocoxib is not intended or approved for use in human medicine.[1][3][4][5][8]

Firocoxib manufactured by Merial was approved for veterinary use in the United States for dogs in July 2004,[9] and for horses in July 2007 as an oral paste (EQUIOXX) and July 2016 as tablets.[10][11]

Firocoxib is also available as a generic medication for horses[11] and for dogs.[9]

References

  1. 1.0 1.1 1.2 "Equioxx- firocoxib tablet, chewable". 14 July 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3f891a61-ce58-4cc1-97e2-a161907ea8eb. 
  2. "Equioxx- firocoxib paste". 24 February 2022. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=17db1d7d-3683-4030-9039-296a882cc072. 
  3. 3.0 3.1 3.2 "Previcox- firocoxib tablet, chewable". 23 July 2020. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e6d96ec6-04a4-4986-ac9d-82aa79b28bd4. 
  4. 4.0 4.1 "Equioxx EPAR". https://www.ema.europa.eu/en/medicines/veterinary/EPAR/equioxx. 
  5. 5.0 5.1 "Previcox EPAR". https://www.ema.europa.eu/en/medicines/veterinary/EPAR/previcox. 
  6. "Pharmacological Regulation in the USA and Pharmacokinetics Parameters of Firocoxib, a Highly Selective Cox-2, by Pain Management in Horses". Journal of Equine Veterinary Science 77: 36–42. June 2019. doi:10.1016/j.jevs.2019.02.007. PMID 31133314. 
  7. "New NSAID Equioxx (firocoxib) Approved by USEF". The Horse. 2 July 2007. http://www.thehorse.com/ViewArticle.aspx?ID=9896. 
  8. Equioxx , European Medicines Agency
  9. 9.0 9.1 "FDA Approves the First Generic Firocoxib Tablets for Dogs". 7 June 2022. https://www.fda.gov/animal-veterinary/cvm-updates/fda-approves-first-generic-firocoxib-chewable-tablets-dogs. 
  10. "Merial launches first firocoxib for horses" (in en). 2007-07-01. https://www.dvm360.com/view/merial-launches-first-firocoxib-horses. 
  11. 11.0 11.1 "FDA Approves the First Generic Firocoxib Tablets for Horses". 1 August 2022. https://www.fda.gov/animal-veterinary/cvm-updates/fda-approves-first-generic-firocoxib-tablets-horses. 

External links