Chemistry:Kebuzone

Kebuzone
Clinical data
Routes of; administration	intramuscular
ATC code	M01AA06 (WHO) ;
Pharmacokinetic data
Elimination half-life	70–100 hours
Excretion	renal
Identifiers
	IUPAC name 4-(3-oxobutyl)-1,2-di(phenyl)pyrazolidine-3,5-dione;
CAS Number	853-34-9 ;
PubChem CID	3824;
DrugBank	DB08940 ;
ChemSpider	3692 ;
UNII	4VD83UL6Y6;
KEGG	D01567 ;
ChEBI	CHEBI:31749 ;
Chemical and physical data
Formula	C19H18N2O3
Molar mass	322.364 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(=O)CCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3;
	InChI InChI=1S/C19H18N2O3/c1-14(22)12-13-17-18(23)20(15-8-4-2-5-9-15)21(19(17)24)16-10-6-3-7-11-16/h2-11,17H,12-13H2,1H3 ; Key:LGYTZKPVOAIUKX-UHFFFAOYSA-N ;
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Short description: NSAID anti-inflammatory medication

Kebuzone (or ketophenylbutazone) is a nonsteroidal anti-inflammatory drug (NSAID) that is used for the treatment of inflammatory conditions such as thrombophlebitis and rheumatoid arthritis (RA).^[1]^[2]^[3]

References

↑ (in German) Austria-Codex. Vienna: Österreichischer Apothekerverlag. 2018. Rheumesser 3 ml-Ampullen.
↑ "KEBUZONE" (in en). NCATS Inxight: Drugs. https://drugs.ncats.io/drug/4VD83UL6Y6.
↑ "Kebuzone". Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (Sixteenth ed.). Amsterdam. 2016. p. 405. ISBN 978-0-444-53716-4. https://books.google.com/books?id=NOKoBAAAQBAJ&dq=Kebuzone&pg=RA3-PA405.

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Original source: https://en.wikipedia.org/wiki/Kebuzone. Read more

[AustriaCodex-1] (in German) Austria-Codex. Vienna: Österreichischer Apothekerverlag. 2018. Rheumesser 3 ml-Ampullen.

[2] "KEBUZONE" (in en). NCATS Inxight: Drugs. https://drugs.ncats.io/drug/4VD83UL6Y6.

[3] "Kebuzone". Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (Sixteenth ed.). Amsterdam. 2016. p. 405. ISBN 978-0-444-53716-4. https://books.google.com/books?id=NOKoBAAAQBAJ&dq=Kebuzone&pg=RA3-PA405.

[1]

[2]

[3]

v t e Nonsteroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
Pyrazolones / Pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
Salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
Acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bumadizone Bufexamac Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
Oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam
Propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
N-Arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Flufenamic acid Flunixin Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid Flutiazin
Coxibs	Apricoxib Celecoxib Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
Other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase/Orgotein Tenidap
Items listed in bold indicate initially developed compounds of specific groups. ^#WHO-EM ^†Withdrawn drugs. ^‡Veterinary use medications.

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Clinical data

Routes of administration	intramuscular
ATC code	M01AA06 (WHO)
Pharmacokinetic data
Elimination half-life	70–100 hours
Excretion	renal
Identifiers
IUPAC name 4-(3-oxobutyl)-1,2-di(phenyl)pyrazolidine-3,5-dione
CAS Number	853-34-9^Y
PubChem CID	3824
DrugBank	DB08940^N
ChemSpider	3692^N
UNII	4VD83UL6Y6
KEGG	D01567^Y
ChEBI	CHEBI:31749^N
Chemical and physical data
Formula	C₁₉H₁₈N₂O₃
Molar mass	322.364 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC(=O)CCC1C(=O)N(N(C1=O)C2=CC=CC=C2)C3=CC=CC=C3
InChI InChI=1S/C19H18N2O3/c1-14(22)12-13-17-18(23)20(15-8-4-2-5-9-15)21(19(17)24)16-10-6-3-7-11-16/h2-11,17H,12-13H2,1H3^N Key:LGYTZKPVOAIUKX-UHFFFAOYSA-N^N
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