Biology:mIR141
 Generic protein structure example |
MicroRNA 141 is a non-coding RNA molecule that in humans is encoded by the MIR141 gene. [1]
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into an RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].
References
Further reading
- "Down-regulation of miR-141 in gastric cancer and its involvement in cell growth". J. Gastroenterol. 44 (6): 556–61. 2009. doi:10.1007/s00535-009-0037-7. PMID 19363643.
- "MicroRNA-141 regulates Smad interacting protein 1 (SIP1) and inhibits migration and invasion of colorectal cancer cells". Dig. Dis. Sci. 55 (8): 2365–72. August 2010. doi:10.1007/s10620-009-1008-9. PMID 19830559.
- "microRNA-141 is involved in a nasopharyngeal carcinoma-related genes network". Carcinogenesis 31 (4): 559–66. April 2010. doi:10.1093/carcin/bgp335. PMID 20053927.
- "Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells". PLOS ONE 5 (1): e8697. January 2010. doi:10.1371/journal.pone.0008697. PMID 20084174. Bibcode: 2010PLoSO...5.8697V.
- "miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer". Oncogene 29 (30): 4297–306. July 2010. doi:10.1038/onc.2010.201. PMID 20514023.
- "MicroRNA silencing of tumor suppressor DLC-1 promotes efficient hepatitis C virus replication in primary human hepatocytes". Hepatology 53 (1): 53–61. January 2011. doi:10.1002/hep.24016. PMID 20967756.
- "Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E". Cell Host Microbe 9 (1): 58–69. January 2011. doi:10.1016/j.chom.2010.12.001. PMID 21238947.
- "MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma". J. Hum. Genet. 56 (4): 270–6. April 2011. doi:10.1038/jhg.2011.1. PMID 21289630.
- "Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis". PLOS ONE 6 (3): e17745. March 2011. doi:10.1371/journal.pone.0017745. PMID 21445232. Bibcode: 2011PLoSO...617745C.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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