Biology:Phosphomevalonate kinase

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example


Phosphomevalonate kinase
Identifiers
EC number2.7.4.2
CAS number9026-46-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Phosphomevalonate kinase
Identifiers
SymbolPMVK
NCBI gene10654
HGNC9141
OMIM607622
RefSeqNM_006556
UniProtQ15126
Other data
EC number2.7.4.2
LocusChr. 1 p13-q23

Phosphomevalonate kinase is an enzyme (EC 2.7.4.2) in the mevalonate pathway[1][2][3] that in humans is encoded by the PMVK gene.

References

  1. "Mevalonic acid pyrophosphate and isopentenylpyrophosphate". The Journal of Biological Chemistry 234 (10): 2595–604. October 1959. doi:10.1016/S0021-9258(18)69744-3. PMID 13801508. 
  2. "Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase". Archives of Biochemistry and Biophysics 83 (1): 259–67. July 1959. doi:10.1016/0003-9861(59)90031-1. PMID 13662013. 
  3. "Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver". The Biochemical Journal 75 (3): 417–28. June 1960. doi:10.1042/bj0750417. PMID 14416398. 

External links