Biology:Bone morphogenetic protein receptor
| TKL Ser/Thr protein kinase family | |
|---|---|
| Identifiers | |
| Symbol | TKL |
| Membranome | 1216 |
Bone morphogenetic protein receptors are serine-threonine kinase receptors. Transforming growth factor beta family proteins bind to these receptors.[1] There are four bone morphogenetic protein receptors:[2]
- Bone morphogenetic protein receptor, type 1:
- Bone morphogenetic protein receptor, type 2
Structure
Both type 1 and 2 bone morphogenetic protein receptors have a single transmembrane segment. Additionally, both types have a cysteine-rich extracellular domain and a cytoplasmic serine threonine kinase domain.[3] Type 1 contains a glycine-serine-rich domain to be phosphorylated by type 2 kinase domain, initiating the signaling transduction pathway of the SMAD signaling cascade.[3] The wrist epitope motif on BMP-2 has a high-affinity binding site for BMPR-IA. The knuckle epitope motif on BMP-2 has a low-affinity binding site for BMPR-II.[4]
See also
References
- ↑ "Bone morphogenetic protein receptors and signal transduction". Journal of Biochemistry 147 (1): 35–51. January 2010. doi:10.1093/jb/mvp148. PMID 19762341.
- ↑ "The TGF Family. Cold Spring Harbor Monograph Series, Volume 50. Edited by Rik Derynck, Kohei Miyazono. Cold Spring Harbor (New York): Cold Spring Harbor Laboratory Press. xiv-1114 p.; ill.; index. 9780879697525. 2008.". The Quarterly Review of Biology 83 (4): 405–405. December 2008. doi:10.1086/596254.
- ↑ 3.0 3.1 "High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding". Biochemical and Biophysical Research Communications 351 (4): 831–8. December 2006. doi:10.1016/j.bbrc.2006.10.109. PMID 17094948.
- ↑ "Chapter 55: Bone morphogenetic protein receptors and actions.". Principles of bone biology (Third ed.). San Diego: Academic Press. January 2008. pp. 1177–1196. doi:10.1016/B978-0-12-373884-4.00069-0. ISBN 978-0-12-373884-4.
External links
- Bone+Morphogenetic+Protein+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
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