Chemistry:BD1063
From HandWiki
Short description: Chemical compound
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| Formula | C13H18Cl2N2 |
| Molar mass | 273.20 g·mol−1 |
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BD1063 or 1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine is a selective sigma receptor antagonist, with a reported binding affinity of Ki = 9 ± 1 nM for the sigma-1 receptor and more than 49 times selectivity over the sigma-2 receptor.[1]
Consistent with other reported sigma receptor antagonists, pretreating Swiss Webster mice with BD1063 significantly decreases the convulsivity and lethality of cocaine.[1]
In other animal studies, BD1063 blocks the effects of MDMA,[2] and reduces alcohol intake in rodent models of alcoholism.[3]
See also
References
- ↑ 1.0 1.1 "Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice". Eur. J. Pharmacol. 419 (2–3): 163–74. 2001. doi:10.1016/s0014-2999(01)00968-2. PMID 11426838.
- ↑ "Interactions between 3,4-methylenedioxymethamphetamine and sigma1 receptors". European Journal of Pharmacology 553 (1–3): 141–5. December 2006. doi:10.1016/j.ejphar.2006.09.038. PMID 17070798.
- ↑ "The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking". Neuropsychopharmacology 34 (6): 1482–93. May 2009. doi:10.1038/npp.2008.192. PMID 18946467.
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