Chemistry:Butaclamol
From HandWiki
Short description: Chemical compound
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Formula | C25H31NO |
Molar mass | 361.529 g·mol−1 |
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Butaclamol (AY-23,028) is a type of antipsychotic which was never marketed.[1] Sold as the hydrochloride salt for use in research, the compound acts as a dopamine receptor antagonist.[2]
Chemistry
pKa = 7.15 (uncorrected for ionic strength)[3]
References
- ↑ Dictionary of organic compounds - Google Books. CRC Press. 1985. ISBN 978-0-412-54090-5. https://books.google.com/books?id=wZawOvjGME0C&q=butaclamol&pg=PA1131.
- ↑ "Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors". British Journal of Pharmacology 121 (4): 731–6. June 1997. doi:10.1038/sj.bjp.0701196. PMID 9208141.
- ↑ "The pKa of butaclamol and the mode of butaclamol binding to central dopamine receptors". Journal of Medicinal Chemistry 28 (3): 399–400. March 1985. doi:10.1021/jm00381a022. PMID 2579238.
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See also: Receptor/signaling modulators |
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Antidepressants (TCAs and TeCAs) |
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Antipsychotics |
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