Chemistry:Butaclamol

From HandWiki

Butaclamol (AY-23,028) is a type of antipsychotic which was never marketed.[1] Sold as the hydrochloride salt for use in research, the compound acts as a dopamine receptor antagonist.[2]

Synthesis:[3] Review:[4] Book chapter:[5]

Chemistry

pKa = 7.15 (uncorrected for ionic strength)[6]

See also

  • Dexclamol

References

  1. ↑ Dictionary of organic compounds - Google Books. CRC Press. 1985. ISBN 978-0-412-54090-5. https://books.google.com/books?id=wZawOvjGME0C&q=butaclamol&pg=PA1131. 
  2. ↑ "Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors". British Journal of Pharmacology 121 (4): 731–6. June 1997. doi:10.1038/sj.bjp.0701196. PMID 9208141. 
  3. ↑ "Neuroleptic agents of the benzocycloheptapyridoisoquinoline series. 1. Syntheses and stereochemical and structural requirements for activity of butaclamol and related compounds". Journal of Medicinal Chemistry 18 (2): 185–188. February 1975. doi:10.1021/jm00236a016. PMID 1168258. 
  4. ↑ "Butaclamol". Drugs of the Future 1 (4): 171. 1976. doi:10.1358/dof.1976.001.04.64761. 
  5. ↑ Chronicles of Drug Discovery, Volume 1, Edited by Jasjit S. Bindra and Daniel Lednicer, page 61, (L. G. Humber).
  6. ↑ "The pKa of butaclamol and the mode of butaclamol binding to central dopamine receptors". Journal of Medicinal Chemistry 28 (3): 399–400. March 1985. doi:10.1021/jm00381a022. PMID 2579238. 



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