Chemistry:Ethylketazocine

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Short description: Chemical compound
Ethylketazocine
Ethylketazocine.svg
Clinical data
Other namesethylketocyclazocine
ATC code
  • None
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
Chemical and physical data
FormulaC19H25NO2
Molar mass299.407 g·mol−1
3D model (JSmol)

Ethylketazocine (WIN-35,197-2), is an opioid drug of the benzomorphan family which has been used extensively in scientific research in the last few decades as a tool to aid in the study of the κ-opioid receptor.[1] However, due to its relatively poor selectivity for the κ-opioid receptor over the μ- and δ-opioid receptors (of which it has approximately 80% and 20% of the affinity for, respectively, in comparison), as well as its relatively poor intrinsic activity at all sites (i.e., acts as a partial agonist with mixed agonist and antagonist properties), it has been mostly replaced in recent times by newer and more potent and selective compounds like U-50,488 and ICI-199,441.[1][2][3]

See also

References

  1. ↑ 1.0 1.1 Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. 24 September 2007. p. 657. ISBN 978-0-7817-6879-5. https://books.google.com/books?id=R0W1ErpsQpkC&pg=PA657. Retrieved 22 April 2012. 
  2. ↑ Imaging Drug Action in the Brain. CRC Press. 1993. p. 130. ISBN 978-0-8493-8843-9. https://books.google.com/books?id=Tg7zuhLGZAYC&pg=PA130. Retrieved 22 April 2012. 
  3. ↑ Opioids in Medicine: A Comprehensive Review on the Mode of Action and the Use of Analgesics in Different Clinical Pain States. Springer. 3 April 2008. p. 103. ISBN 978-1-4020-5946-9. https://books.google.com/books?id=ybtX0GZGhk8C&pg=PA103. Retrieved 22 April 2012. 




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