Chemistry:Fourphit

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Fourphit, also known as 4-isothiocyanato-PCP, is an irreversible dopamine transporter (DAT) blocker and a reversible NMDA receptor antagonist.[1][2] It blocks the binding of methylphenidate to the DAT in vitro,[1] though apparently not in vivo.[2] In any case, the drug reduces the stimulant-like effects of cocaine in animals,[2] whilst producing mostly negligible behavioral effects itself.[2] Fourphit is an acylating derivative of phencyclidine (PCP) and a positional isomer of metaphit (3-isothiocyanato-PCP).[1]

See also

References

  1. ↑ 1.0 1.1 1.2 "Fourphit: a selective probe for the methylphenidate binding site on the dopamine transporter". J Pharmacol Exp Ther 261 (3): 936–942. June 1992. doi:10.1016/S0022-3565(25)11167-1. PMID 1602399. 
  2. ↑ 2.0 2.1 2.2 2.3 "Fourphit, an acylating phencyclidine derivative, attenuates cocaine-induced hyperactivity in rats". Pharmacol Biochem Behav 60 (3): 615–623. July 1998. doi:10.1016/s0091-3057(98)00040-9. PMID 9678644. 




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