Chemistry:Clorgiline
Clorgiline (INN), or clorgyline (BAN), is a monoamine oxidase inhibitor (MAOI) structurally related to pargyline which is described as an antidepressant.[1][2] Specifically, it is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A).[3] Clorgiline was never marketed,[1] but it has found use in scientific research.[4] It has been found to bind with high affinity to the σ1 receptor (Ki = 3.2 nM)[3][5] and with very high affinity to the I2 imidazoline receptor (Ki = 40 pM).[6]
Unlike selegiline, clorgiline does not appear to be a monoaminergic activity enhancer (MAE).[7][8][9][10]
Clorgiline is also a multidrug efflux pump inhibitor.[11] Holmes et al., 2012 reverse azole fungicide resistance using clorgiline, showing promise for its use in multiple fungicide resistance.[11]
References
- ↑ 1.0 1.1 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 304–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA304.
- ↑ Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 6 December 2012. pp. 80–. ISBN 978-94-011-4439-1. https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA80.
- ↑ 3.0 3.1 Acetylcholine, Sigma Receptors, CCK and Eicosanoids, Neurotoxins. Taylor & Francis. January 1993. pp. 124–. ISBN 978-0-7484-0063-8. https://books.google.com/books?id=0xmt5kSpJEcC&pg=PA124.
- ↑ "Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (Clorgyline) or MAO-B (Selegiline and pargyline)". MAO — the Mother of all Amine Oxidases. Journal of Neural Transmission. Supplement. 52. 1998. pp. 39–48. doi:10.1007/978-3-7091-6499-0_5. ISBN 978-3-211-83037-6.
- ↑ Sigma Receptors. Academic Press. 1994. p. 84. ISBN 978-0-12-376350-1. https://books.google.com/books?id=ndRqAAAAMAAJ.
- ↑ "Psychopharmacology of imidazoline and alpha 2-adrenergic receptors: implications for depression". Critical Reviews in Neurobiology 9 (1): 29–66 (43). 1994. PMID 8828003. https://books.google.com/books?id=EP9FAQAAIAAJ.
- ↑ "Pharmacological studies with endogenous enhancer substances: β-phenylethylamine, tryptamine, and their synthetic derivatives". Prog Neuropsychopharmacol Biol Psychiatry 28 (3): 421–427. May 2004. doi:10.1016/j.pnpbp.2003.11.016. PMID 15093948.
- ↑ "Deprenyl (selegiline): the history of its development and pharmacological action". Acta Neurol Scand Suppl 95: 57–80. 1983. doi:10.1111/j.1600-0404.1983.tb01517.x. PMID 6428148.
- ↑ "The pharmacological profile of (-)deprenyl (selegiline) and its relevance for humans: a personal view". Pharmacology & Toxicology 70 (5 Pt 1): 317–321. May 1992. doi:10.1111/j.1600-0773.1992.tb00480.x. PMID 1608919.
- ↑ "The aphrodisiac effect of low doses of (-) deprenyl in male rats". Pol J Pharmacol Pharm 34 (5–6): 303–308. 1982. PMID 6821215.
- ↑ 11.0 11.1
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Slovene pronunciation: [{{{1}}}]Thai pronunciation: [{{{1}}}]Neukirch, Jürgen; Schmidt, Alexander; Wingberg, Kay (2000), Cohomology of Number Fields, Grundlehren der Mathematischen Wissenschaften, 323, Berlin: Springer-Verlag, ISBN 978-3-540-66671-4Template:ScribuntoPersian pronunciation: [{{{1}}}]{| class="wikitable" width="100%"This page may be too long to read and navigate comfortably.! rowspan="3" colspan="2" width="14%" style="border-bottom:2px solid grey;" | Date/Time (UTC) ! Configuration ! Serial number ! Launch site ! Outcome |-
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String suggested In progressPalomares, M. L. D. and Pauly, D., eds. (2011). "{{{1}}} {{{2}}}" in SeaLifeBase. April 2011 version.Turkish pronunciation: [{{{1}}}]Finnish pronunciation: [{{{1}}}]Froese, Rainer and Pauly, Daniel, eds. (2006). "{{{1}}} {{{2}}}" in FishBase. April 2006 version.
|- | ... | — | — | — | — | — | —
|-Old Norse pronunciation: [{{{1}}}]Salish pronunciation: [{{{1}}}]Basque pronunciation: [{{{1}}}]{{{1}}}data-sort-value="" style="background: #ececec; color: #2C2C2C; vertical-align: middle; font-size: smaller; text-align: center; " class="table-na" | UnreleasedNorwegian pronunciation: [{{{1}}}] (aged {{{4}}})Hungarian pronunciation: [{{{1}}}]Quechua pronunciation: [{{{1}}}]Arabic pronunciation: [{{{1}}}]Punjabi pronunciation: [{{{1}}}]Afrikaans pronunciation: [{{{1}}}]Romanian pronunciation: [{{{1}}}]Hebrew pronunciation: [{{{1}}}][INVALID OR MISSING PARAMETER IN TEMPLATE Clorgiline]Uto-Aztecan pronunciation: [{{{1}}}]Tamil pronunciation: [{{{1}}}]Hindustani pronunciation: [{{{1}}}]Swedish pronunciation: [{{{1}}}]Kazakh pronunciation: [{{{1}}}]Lao pronunciation: [{{{1}}}]Tibetan pronunciation: [{{{1}}}]Khmer pronunciation: [{{{1}}}]data-sort-value="" style="vertical-align:middle; text-align:center" class="table-na" | —{{{1}}}Welsh pronunciation: [{{{1}}}] Partially doneAthabaskan pronunciation: [{{{1}}}]Māori pronunciation: [{{{1}}}]IPA: [{{{1}}}]Bulgarian pronunciation: [{{{1}}}]Korean pronunciation: [{{{1}}}]Icelandic pronunciation: [{{{1}}}]Sanskrit pronunciation: [{{{1}}}]Bengali pronunciation: [{{{1}}}]Indonesian pronunciation: [{{{1}}}]Serbo-Croatian pronunciation: [{{{1}}}]CROSBI {{{1}}} "The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates". Antimicrobial Agents and Chemotherapy (American Society for Microbiology) 56 (3): 1508–1515. March 2012. doi:10.1128/aac.05706-11. PMID 22203607.
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