Chemistry:Clorgiline
From HandWiki
Short description: Chemical compound
 | |
| Clinical data | |
|---|---|
| ATC code |
|
| Legal status | |
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| IUPHAR/BPS | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C13H15Cl2NO |
| Molar mass | 272.17 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
  (what is this?) (verify) | |
Clorgiline (INN), or clorgyline (BAN), is a monoamine oxidase inhibitor (MAOI) structurally related to pargyline which is described as an antidepressant.[1][2] Specifically, it is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A).[3] Clorgiline was never marketed,[1] but it has found use in scientific research.[4] It has been found to bind with high affinity to the σ1 receptor (Ki = 3.2 nM)[3][5] and with very high affinity to the I2 imidazoline receptor (Ki = 40 pM).[6]
Clorgiline is also a multidrug efflux pump inhibitor.[7] Holmes et al., 2012 reverse azole fungicide resistance using clorgiline, showing promise for its use in multiple fungicide resistance.[7]
References
- ↑ 1.0 1.1 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. pp. 304–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA304.
- ↑ Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. 6 December 2012. pp. 80–. ISBN 978-94-011-4439-1. https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA80.
- ↑ 3.0 3.1 Acetylcholine, Sigma Receptors, CCK and Eicosanoids, Neurotoxins. Taylor & Francis. January 1993. pp. 124–. ISBN 978-0-7484-0063-8. https://books.google.com/books?id=0xmt5kSpJEcC&pg=PA124.
- ↑ "Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (Clorgyline) or MAO-B (Selegiline and pargyline)". MAO — the Mother of all Amine Oxidases. Journal of Neural Transmission. Supplement. 52. 1998. pp. 39–48. doi:10.1007/978-3-7091-6499-0_5. ISBN 978-3-211-83037-6.
- ↑ Sigma Receptors. Academic Press. 1994. p. 84. ISBN 978-0-12-376350-1. https://books.google.com/books?id=ndRqAAAAMAAJ.
- ↑ "Psychopharmacology of imidazoline and alpha 2-adrenergic receptors: implications for depression". Critical Reviews in Neurobiology 9 (1): 29–66 (43). 1994. PMID 8828003. https://books.google.com/books?id=EP9FAQAAIAAJ.
- ↑ 7.0 7.1
- • "Resistance to antifungal therapies". Essays in Biochemistry (Portland Press (Biochemical Society)) 61 (1): 157–166. February 2017. doi:10.1042/ebc20160067. PMID 28258238.
- • "The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates". Antimicrobial Agents and Chemotherapy (American Society for Microbiology) 56 (3): 1508–1515. March 2012. doi:10.1128/aac.05706-11. PMID 22203607.
 |  |
