Chemistry:Sarolaner
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| Trade names | Simparica |
| Other names | PF-6450567 |
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| Formula | C23H18Cl2F4N2O5S |
| Molar mass | 581.36 g·mol−1 |
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Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs.[2][3] It is also used off-label to control sarcoptic mange and demodectic mange.[3]
Sarolaner is also a component of the combination drug Simparica Trio, which contains sarolaner, moxidectin, and pyrantel.[4] It is used for prevention of heartworm disease caused by Dirofilaria immitis; treat and prevent flea infestations; treat and control tick infestations with the lone star tick, Gulf Coast tick, American dog tick, black-legged tick, and brown dog tick; and treat and control roundworm and adult hookworm infections.[5]
Sarolaner is also an ingredient in feline combination antiparasitic Revolution Plus (or Stronghold Plus[6]), which contains sarolaner and selamectin and is used for prevention of sarcoptic mange, feline hookworms, feline roundworms, ear mites, and heartworms, as well as treating and preventing fleas and ticks.[7]
References
- ↑ "Simparica". https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141-452.
- ↑ "Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs". Veterinary Parasitology 222: 3–11. May 2016. doi:10.1016/j.vetpar.2016.02.019. PMID 26961590. https://discovery.dundee.ac.uk/ws/files/49833501/1_s2.0_S0304401716300425_main.pdf.
- ↑ 3.0 3.1 "Sarolaner". VCA Hospitals. https://vcahospitals.com/know-your-pet/sarolaner.
- ↑ "Simparica Trio". https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141-521.
- ↑ "FDA Approves Simparica Trio, a Combination Drug for Heartworm and Other Parasites". U.S. Food and Drug Administration (FDA). 2 March 2020. https://www.fda.gov/animal-veterinary/cvm-updates/fda-approves-simparica-trio-combination-drug-heartworm-and-other-parasites.
- ↑ "Stronghold Plus". https://www.ema.europa.eu/en/medicines/veterinary/EPAR/stronghold-plus.
- ↑ "Revolution Plus". https://animaldrugsatfda.fda.gov/adafda/views/#/home/previewsearch/141-502.
External links
- "Sarolaner". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/sarolaner.
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