Chemistry:Ryanoid
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Short description: Class of insecticide
Ryanoids are a class of insecticides which share the same mechanism of action as the alkaloid ryanodine. Ryanodine is a naturally occurring insecticide isolated from Ryania speciosa.
Ryanoids include natural chemicals which are closely related to ryanodine, such as ryanodol and 9,21-didehydroryanodol,[1] and also chemically distinct synthetic compounds such as chlorantraniliprole (Rynaxypyr), flubendiamide, cyantraniliprole, cyclaniliprole, and tetraniliprole (Tetrino), which are called diamide insecticides.[2][3]
Ryanoids exert their insecticidal effect by interacting with ryanodine receptors, a type of calcium channel. This causes loss of muscle function[3] leading to paralysis and death.
References
- ↑ Usherwood, P.N.R.; Vais, H. (1995). "Towards the development of ryanoid insecticides with low mammalian toxicity". Toxicology Letters 82-83: 247–54. doi:10.1016/0378-4274(95)03558-3. PMID 8597061.
- ↑ Teixeira, Luís A; Andaloro, John T (2013). "Diamide insecticides: Global efforts to address insect resistance stewardship challenges". Pesticide Biochemistry and Physiology 106 (3): 76–78. doi:10.1016/j.pestbp.2013.01.010.
- ↑ 3.0 3.1 IRAC International MoA Working Group (March 2020). "IRAC Mode of Action Classification Scheme Version 9.4". Insecticide Resistance Action Committee. http://irac-online.org/documents/moa-classification/.
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