Chemistry:Pyriprole
Pyriprole, sold under the brand name Prac-tic, is a veterinary medication used for dogs against external parasites such as fleas and ticks.[1][2]
Pyriprole is a phenylpyrazole derivative similar to fipronil.[3] Introduced in the 2000s[4] and under patent protection[5] as an insecticide, It is only approved in the EU and a few other countries for use on dogs specifically.[6][7]
Pyriprole applied as a spot-on is highly effective against fleas and several tick species.[8] Efficacy against fleas is comparable to that of other modern insecticidal active ingredients such as fipronil, imidacloprid or spinosad.[8][9][10][11] As with most flea spot-ons it controls existing flea and tick infestations in about 1 to 2 days, and provides about 4 weeks protection against re-infestations.[7]
Mechanism of action
Pyriprole is an insecticide and acaricide. It inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) resulting in uncontrolled hyperactivity of the central nervous system of fleas and ticks.[12]
Parasites are killed through contact rather than by systemic exposure. Following topical administration pyriprole is rapidly distributed in the hair coat of dogs within one day after application. It can be found in the hair coat throughout the treatment interval. Insecticidal efficacy duration against new infestations with fleas persists for a minimum of four weeks. The substance can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD).[7]
References
- ↑ "Antiparasitic Drugs". Small Animal Clinical Pharmacology (Second ed.). [Edinburgh]: Elsevier Health Sciences. 2008. pp. 198–260 (229). doi:10.1016/B978-070202858-8.50012-9. ISBN 978-0-7020-2858-8. https://books.google.com/books?id=RpsROVqemk8C&dq=Pyriprole&pg=PA229.
- ↑ "Ectoparasiticides – Antagonists and Modulators of Chloride Channels". Encyclopedia of Parasitology (3rd ed.). Berlin: Springer Rechtswissenschaft. 2008. p. 431. ISBN 978-3-540-48994-8. https://books.google.com/books?id=Jpg1ysgVn-AC&dq=Pyriprole&pg=PA431.
- ↑ "Phenylpyrazoles: Ethiprole and Fipronil". Modern Crop Protection Compounds (1 ed.). Wiley. 2026-05-11. pp. 1744–1781. doi:10.1002/9783527843879.ch41.7.1. ISBN 978-3-527-35250-0.
- ↑ "Public Health - European Commission". https://ec.europa.eu/health/documents/community-register/html/v066.htm.
- ↑ D·弗斯特 E, H·奥隆米-萨迪吉, "pesticide mixture", patent CN101605461A, issued 2009-12-16
- ↑ University of Hertfordshire. "Pyriprole (Ref: V3086)". https://sitem.herts.ac.uk/aeru/vsdb/Reports/1370.htm.
- ↑ 7.0 7.1 7.2 "Prac-tic, INN-Pyriprole". https://ec.europa.eu/health/documents/community-register/2016/20160725135485/anx_135485_en.pdf.
- ↑ 8.0 8.1 "Efficacy of a single application of a 12.5% pyriprole topical solution against laboratory infestations with ticks (Ixodes ricinus, Dermacentor reticulatus, and Rhipicephalus sanguineus) on dogs". Veterinary Parasitology 154 (3–4): 311–317. July 2008. doi:10.1016/j.vetpar.2008.03.007. PMID 18455315.
- ↑ "Comparative efficacy of imidacloprid, selamectin, fipronil-(S)-methoprene, and metaflumizone against cats experimentally infested with Ctenocephalides felis". Veterinary Therapeutics: Research in Applied Veterinary Medicine 9 (3): 176–183. 2008. PMID 19003778.
- ↑ "Imidacloprid". Encyclopedia of Toxicology (Second Edition). New York: Elsevier. 2005-01-01. pp. 567–570. doi:10.1016/B0-12-369400-0/00513-5. ISBN 978-0-12-369400-3.
- ↑ "Effectiveness of spinosad as a grain protectant against resistant beetle and psocid pests of stored grain in Australia". Journal of Stored Products Research 41 (4): 455–467. 2005-01-01. doi:10.1016/j.jspr.2004.07.002. ISSN 0022-474X.
- ↑ "Pyriprole". Encyclopedia of Parasitology. Berlin, Heidelberg: Springer Berlin Heidelberg. 2016. pp. 2298. doi:10.1007/978-3-662-43978-4_2623. ISBN 978-3-662-43977-7. http://link.springer.com/10.1007/978-3-662-43978-4_2623. Retrieved 2025-10-30.
 |  |
