Biology:mir-711 microRNA precursor family
From HandWiki
| mir-711 | |
|---|---|
| Identifiers | |
| Symbol | mir-711 |
| Rfam | RF01923 |
| miRBase family | MIPF0000748 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-711 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Diagnostic use in Cutaneous T-cell Lymphoma
miR-711 is able to distinguish between malignant cutaneous T-cell lymphomas and benign skin disorders with high accuracy.[1]
Hsp70.3 and Further Regulation
miR-711 has been found to target and suppress Heat Shock Protein 70.3 in vitro at a post-transcriptional level via its 3' untranslated region.[2] Ischaemic preconditioning brings about reduced miR-711 levels, with downregulated cardiac myocyte levels further dependent upon NF-kappa B.
See also
References
- ↑ "Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)". Blood 118 (22): 5891–900. November 2011. doi:10.1182/blood-2011-06-358382. PMID 21865341.
- ↑ "Coordinated post-transcriptional regulation of Hsp70.3 gene expression by microRNA and alternative polyadenylation". The Journal of Biological Chemistry 286 (34): 29828–37. August 2011. doi:10.1074/jbc.M111.221796. PMID 21757701.
Further reading
- "Alteration of microRNA expression correlates to fatty acid-mediated insulin resistance in mouse myoblasts". Molecular BioSystems (Royal Society of Chemistry) 7 (3): 871–7. March 2011. doi:10.1039/c0mb00230e. PMID 21183973.
External links
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