Biology:mir-370 microRNA precursor family

mir-370
Identifiers
Symbol	mir-370
Rfam	RF00740
miRBase family	MIPF0000167
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-370 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. This microRNA, mir-370-3p, has been shown to play a role in heart failure. The upregulation of mir-370-3p in the sinus node leads to downregulation of the pacemaker ion channel, HCN4, and thus downregulation of the corresponding ionic current, which causes sinus bradycardia.

See also

• MicroRNA

Further reading

• "Expression of BMP-2 and Ets1 in BMP-2-stimulated mouse pre-osteoblast differentiation is regulated by microRNA-370". FEBS Letters 586 (12): 1693–701. June 2012. doi:10.1016/j.febslet.2012.04.014. PMID 22587915. 
• "Plasma levels of lipometabolism-related miR-122 and miR-370 are increased in patients with hyperlipidemia and associated with coronary artery disease". Lipids in Health and Disease 11 (1): 55. May 2012. doi:10.1186/1476-511X-11-55. PMID 22587332. 
• "MicroRNA profiles in familial and sporadic medullary thyroid carcinoma: Preliminary relationships with RET status and outcome". Thyroid 22 (9): 890–6. 2012. doi:10.1089/thy.2012-0045. PMID 22747440. 
• "MicroRNAs: emerging roles in lipid and lipoprotein metabolism". Current Opinion in Lipidology 23 (3): 220–5. June 2012. doi:10.1097/MOL.0b013e3283534c9f. PMID 22488426. 
• "Integrated analysis of mRNA and microRNA expression in mature neurons, neural progenitor cells and neuroblastoma cells". Gene 495 (2): 120–7. March 2012. doi:10.1016/j.gene.2011.12.041. PMID 22244746. 
• "Overexpression of miR-370 and downregulation of its novel target TGFβ-RII contribute to the progression of gastric carcinoma". Oncogene 31 (2): 226–37. January 2012. doi:10.1038/onc.2011.226. PMID 21666718. 
• "The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer". British Journal of Cancer 104 (5): 808–18. March 2011. doi:10.1038/bjc.2011.23. PMID 21304530. 
• "MicroRNAs in lipid metabolism". Current Opinion in Lipidology 22 (2): 86–92. April 2011. doi:10.1097/MOL.0b013e3283428d9d. PMID 21178770. 
• "Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma". The Journal of Pathology 223 (1): 72–80. January 2011. doi:10.1002/path.2802. PMID 21125666. 
• "microRNAs and cholesterol metabolism". Trends in Endocrinology and Metabolism 21 (12): 699–706. December 2010. doi:10.1016/j.tem.2010.08.008. PMID 20880716. 
• "The peripheral blood mononuclear cell microRNA signature of coronary artery disease". Biochemical and Biophysical Research Communications 394 (3): 792–7. April 2010. doi:10.1016/j.bbrc.2010.03.075. PMID 20230787. 
• "MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism". Journal of Lipid Research 51 (6): 1513–23. June 2010. doi:10.1194/jlr.M004812. PMID 20124555. 
• "Regulation of hepatic microRNA expression in response to ischemic preconditioning following ischemia/reperfusion injury in mice". OMICS 13 (6): 513–20. December 2009. doi:10.1089/omi.2009.0035. PMID 19780683. 
• "Localization- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co-expressed miRNAs located at 14q32.31". The Journal of Pathology 220 (1): 71–86. January 2010. doi:10.1002/path.2610. PMID 19768731. 
• "MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats". Clinical and Experimental Pharmacology & Physiology 36 (2): 181–8. February 2009. doi:10.1111/j.1440-1681.2008.05057.x. PMID 18986336. 
• Seoighe, Cathal, ed (May 2008). "Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia". PLOS ONE 3 (5): e2141. doi:10.1371/journal.pone.0002141. PMID 18478077. Bibcode: 2008PLoSO...3.2141D. 
• "Epigenetic regulation of microRNA-370 by interleukin-6 in malignant human cholangiocytes". Oncogene 27 (3): 378–86. January 2008. doi:10.1038/sj.onc.1210648. PMID 17621267. 

External links

• Page for mir-370 microRNA precursor family at Rfam