Biology:mir-399 microRNA precursor family

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mir-399 microRNA precursor family
RF00445.jpg
Predicted secondary structure and sequence conservation of mir-399
Identifiers
Symbolmir-399
RfamRF00445
miRBaseMI0001020
miRBase familyMIPF0000015
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GO0035195 0035068
SO0001244
PDB structuresPDBe

mir-399 is a microRNA that was identified in both Arabidopsis thaliana and Oryza sativa computationally and was later experimentally verified. mir-399 is thought to target mRNAs coding for a phosphate transporter.[1] The mature sequence is excised from the 3' arm of the hairpin. There are multiple copies of MIR399 in each plant genome, for example A. thaliana contains six microRNA precursors that all give rise to an almost identical mature miR-399 sequence.

References

  1. Jones-Rhoades, MW; Bartel DP (2004). "Computational Identification of Plant MicroRNAs and Their Targets, Including a Stress-Induced miRNA". Mol Cell 14 (6): 787–799. doi:10.1016/j.molcel.2004.05.027. PMID 15200956. 

Further reading

  • "Target mimicry provides a new mechanism for regulation of microRNA activity". Nat. Genet. 39 (8): 1033–7. August 2007. doi:10.1038/ng2079. PMID 17643101. 

External links