Chemistry:Biapenem

From HandWiki

Biapenem (INN) is a carbapenem antibiotic sold in Japan under the brand name Omegacin,[1] and in India as Bianem.[2][3] It is a synthetic β-lactam antibiotic belonging to the carbapenems chemical class, developed by the Japanese subsidiary of Lederle Pharmaceuticals in the late 1980's.[4]

Biapenem was approved for use in Japan in 2001, and launched to market there in 2002,[5] with clinical trials approved in India in 2021,[2] and full market launch later the same year.[3] In clinical trials, it was found to be more effective at lower doses than Imipenem, but less effective than equivalent doses of Ceftazidime.[4]

Medical Uses

Biapenem is effective against a wide range of gram-positive and gram-negative bacteria[6][7], including Escherichia coli, Klebsiella pneumoniae, Klebsiella aerogenes, Enterobacter cloacae, Citrobacter freundii, Serratia marcescens, Proteus mirabilis, Proteus vulgaris, and Morganella morganii.[4]

Unlike some other Carbapenems, notably Imipenem, Biapenem is not particularly susceptible to hydrolysis by human renal dihydropeptidase-I (DHP-I), meaning it can be administered effectively without an adjunct like Cilastatin.[8]

Resistance to Biapenem is similar to that of Imipenem, with similar mechanisms responsible.[9] It is most frequently given as an intravenous infusion.[10]

References

  1. ↑ "In vitro activity of biapenem (L-627), a new carbapenem, against anaerobes". Antimicrob. Agents Chemother. 38 (4): 889–93. April 1994. doi:10.1128/aac.38.4.889. PMID 8031067. 
  2. ↑ 2.0 2.1 "Permission to conduct Clinical Trial for Biapenem Injection 300 mg (Form CT-06, File No. ND/MA/21/000018)". Central Drugs Standard Control Organization (CDSCO), Government of India. 2021-04-22. https://www.cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadCTApprovals/23%20Hetero%20Biapenem%20CT-06.pdf. 
  3. ↑ 3.0 3.1 Sharma, Ruchika (2021-09-25). "BDR Pharma gets DCGI nod for generic antibiotic drug Biapenem". Medical Dialogues. https://medicaldialogues.in/news/industry/pharma/bdr-pharma-gets-dcgi-nod-for-generic-antibiotic-drug-biapenem-82384. 
  4. ↑ 4.0 4.1 4.2 Ubukata, K; Hikida, M; Yoshida, M; Nishiki, K; Furukawa, Y; Tashiro, K; Konno, M; Mitsuhashi, S (June 1990). "In vitro activity of LJC10,627, a new carbapenem antibiotic with high stability to dehydropeptidase I". Antimicrobial Agents and Chemotherapy 34 (6): 994–1000. doi:10.1128/aac.34.6.994. PMID 2203313. PMC 171745. https://journals.asm.org/doi/10.1128/aac.34.6.994. 
  5. ↑ Goldstein, Ellie J. C.; Citron, Diane M.; Tyrrell, Kerin L.; Merriam, C. Vreni (June 2013). "In Vitro Activity of Biapenem plus RPX7009, a Carbapenem Combined with a Serine β-Lactamase Inhibitor, against Anaerobic Bacteria" (in en). Antimicrobial Agents and Chemotherapy 57 (6): 2620–2630. doi:10.1128/AAC.02418-12. ISSN 0066-4804. PMID 23529731. PMC 3716157. https://journals.asm.org/doi/10.1128/AAC.02418-12. 
  6. ↑ Kozawa, Osamu; Uematsu, Toshihiko; Matsuno, Hiroyuki; Niwa, Masayuki; Takiguchi, Yoshiharu; Matsumoto, Syouzou; Minamoto, Masahiko; Niida, Yoshito et al. (June 1998). "Pharmacokinetics and Safety of a New Parenteral Carbapenem Antibiotic, Biapenem (L-627), in Elderly Subjects". Antimicrobial Agents and Chemotherapy 42 (6): 1433–1436. doi:10.1128/aac.42.6.1433. https://journals.asm.org/doi/full/10.1128/aac.42.6.1433. 
  7. ↑ "Principles of drug therapy in geriatric patients". American Family Physician 45 (6): 2709–2718. June 1992. PMID 1595518. 
  8. ↑ Perry, Caroline M.; Ibbotson, Tim (2002). "Biapenem:" (in en). Drugs 62 (15): 2221–2234. doi:10.2165/00003495-200262150-00005. ISSN 0012-6667. http://link.springer.com/10.2165/00003495-200262150-00005. 
  9. ↑ "In-vitro activity of biapenem, compared with imipenem and meropenem, against Pseudomonas aeruginosa strains and mutants with known resistance mechanisms" (in en). Journal of Antimicrobial Chemotherapy 33 (5): 949–958. 1994. doi:10.1093/jac/33.5.949. ISSN 0305-7453. https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/33.5.949. 
  10. ↑ (in ja)The Japanese Journal of Antibiotics 52 (11): 629–660. November 1999. PMID 10659441. 



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