Chemistry:Ceftibuten
 | |
| Clinical data | |
|---|---|
| Trade names | Cedax |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a698023 |
| ATC code | |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| DrugBank | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEBI | |
| ChEMBL | |
| Chemical and physical data | |
| Formula | C15H14N4O6S2 |
| Molar mass | 410.42 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
Ceftibuten is a third-generation cephalosporin antibiotic.[1][2] It is an orally administered agent, with two dosage forms, capsule or oral suspension. It is marketed by Pernix Therapeutics under the trade name Cedax.
Medical uses
Ceftibuten is used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis. It is also indicated for pneumonia, infections of the urinary tract, enteritis, and gastroenteritis.[citation needed]
Adverse effects
In 3,000 patients, ceftibuten was well tolerated. The most frequent reactions were gastrointestinal and nausea.[citation needed]
Susceptibility
Ceftibuten is active against Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Klebsiella pneumoniae, K. oxytoca, Proteus vulgaris, P. mirabilis, P. providence, Salmonella sp., Shigella sp., Enterobacter sp., and Streptococcus sp.[citation needed]
The following represents minimum inhibitory concentration (MIC) susceptibility data for a few clinically significant microorganisms:
- Haemophilus influenzae: 0.015–1.0 μg/ml
- Moraxella catarrhalis: 0.5–4.0 μg/ml
- Streptococcus pneumoniae: 0.5–256 μg/ml [3]
References
- ↑ "Ceftibuten: an overview". Pharmacotherapy 17 (4): 707–20. 1997. doi:10.1002/j.1875-9114.1997.tb03746.x. PMID 9250548.
- ↑ "Ceftibuten: a new expanded-spectrum oral cephalosporin". The Annals of Pharmacotherapy 31 (9): 1022–33. September 1997. doi:10.1177/106002809703100913. PMID 9296244.
- ↑ "Ceftibuten Susceptibility and Minimum Inhibitory Concentration Range (MIC) Data". TOKU-E. June 2020. http://www.toku-e.com/Assets/MIC/Ceftibuten.pdf.
External links
 |  |
