Chemistry:Cefteram
From HandWiki
Cefteram (INN) is a third-generation cephalosporin antibiotic.[1]
Synthesis
- upright=2
The reaction of 7-aminocephalosporanic acid (1) with the methyl-substituted tetrazole (2) gives the intermediate (3). Protection with diazodiphenylmethane (4) produces (5). Amide formation with the thiazole carboxylic acid (6) gives (7), which is deprotected with trifluoroacetic acid to yield cefteram.[2][3]
References
- ↑ "[In vitro antibacterial activities of cefteram and other beta-lactam agents against recent clinical isolates]". The Japanese Journal of Antibiotics 51 (1): 11–25. January 1998. PMID 9557273.
- ↑ "Cefteram". https://www.chemdrug.com/article/8/3284/16419968.html.
- ↑ Hiroshi Sadaki, et al., US patent 4489072, issued 1984-12-18, assigned to Toyama Chemical Co Ltd
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