Chemistry:Cefsulodin
From HandWiki
Short description: Chemical compound
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| Formula | C22H21N4O8S2+ |
| Molar mass | 533.55 g·mol−1 |
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Cefsulodin is a third-generation cephalosporin antibiotic that is active against Pseudomonas aeruginosa and was discovered by Takeda Pharmaceutical Company in 1977.[1][2][3][4]
TAP Pharmaceuticals had a new drug application on file with FDA for cefsulodin under the brand name Cefonomil as of 1985.[5]
Cefsulodin is most commonly used in cefsulodin-irgasan-novobiocin agar to select for Yersinia microorganisms.[6] This agar is most often used in water and beverage testing.[citation needed]
Susceptibility data
The following represents MIC susceptibility data for various P. aeruginosa strains:[7]
- Pseudomonas aeruginosa PA13 (resistant strain): 32 μg/ml
- Pseudomonas aeruginosa (wild-type, susceptible): 4 - 8 μg/ml
References
- ↑ "TOKU-E Technical Application Sheet". https://www.toku-e.com/Upload/Products/Article/20110323002554.pdf.
- ↑ "Cefsulodin and ceftazidime, two antipseudomonal cephalosporins". Clinical Pharmacy 3 (4): 373–85. 1984. PMID 6380902.
- ↑ "Activity of cefsulodin and other agents against Pseudomonas aeruginosa". Reviews of Infectious Diseases 6 (Suppl 3): S667–77. 1984. doi:10.1093/clinids/6.supplement_3.s667. PMID 6443768.
- ↑ "Cefsulodin". Drug Intelligence & Clinical Pharmacy 20 (11): 845–9. November 1986. doi:10.1177/106002808602001104. PMID 3536385.
- ↑ "Lupron Is First Abbott-Takeda Product to Reach U.S. Market". Pink Sheet. 15 April 1985. https://pink.pharmamedtechbi.com/PS008170/LUPRON-IS-FIRST-ABBOTTTAKEDA-PRODUCT-TO-REACH-US-MARKET-FDA-APPROVES-SYNTHETIC-LHRH-ANALOG-WAS-TREATED-AS-1A-BREAKTHROUGH-FOR-PROSTATE-CANCER.
- ↑ "BAM Media M35: Cefsulodin-Irgasan Novobiocin Agar or Yersinia Selective Agar". https://www.fda.gov/Food/ScienceResearch/LaboratoryMethods/BacteriologicalAnalyticalManualBAM/ucm064575.htm.
- ↑ "Cefsulodin | the Antimicrobial Index Knowledgebase - TOKU-E". http://antibiotics.toku-e.com/antimicrobial_474.html.
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