Chemistry:Cefacetrile
From HandWiki
Short description: Chemical compound
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| Trade names | Celospor, Celtol, Cristacef |
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| Routes of administration | Intravenous, intramuscular, intramammary |
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| Protein binding | 23 to 38% |
| Elimination half-life | 1.2 hours |
| Excretion | Renal (72%) |
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| Formula | C13H13N3O6S |
| Molar mass | 339.32 g·mol−1 |
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Cefacetrile (INN, also spelled cephacetrile) is a broad-spectrum first generation cephalosporin antibiotic effective in gram-positive and gram-negative bacterial infections. It is a bacteriostatic antibiotic.[1][2] Cefacetrile is marketed under the trade names Celospor, Celtol, and Cristacef,[3] and as Vetimast for the treatment of mammary infections in lactating cows.[2]
Synthesis
Cefacetrile synthesis: NL patent 6600586 (1966 to Ciba-Geigy).
It was made by reacting 7-ACA (7-aminocephalosporanic acid) with cyanoacetyl chloride in the presence of tributylamine.[citation needed]
References
- ↑ "Cefacetrile Summary Report". European Medicines Agency, Committee for Veterinary Medicinal Products. 1998. http://www.emea.europa.eu/docs/en_GB/document_library/Maximum_Residue_Limits_-_Report/2009/11/WC500011465.pdf.
- ↑ 2.0 2.1 (in German) Austria-Codex (2007/2008 ed.). Vienna: Österreichischer Apothekerverlag. 2007. ISBN 978-3-85200-183-8.
- ↑ "[Clinical evaluation of cephacetrile (Celtol) for respiratory infections (author's transl)]". The Japanese Journal of Antibiotics 33 (10): 1145–55. October 1980. PMID 7206219.
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