Chemistry:Cefmetazole
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| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a601206 |
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| Formula | C15H17N7O5S3 |
| Molar mass | 471.53 g·mol−1 |
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Cefmetazole is a cephamycin antibiotic, usually grouped with the second-generation cephalosporins.
Adverse effects
The chemical structure of cefmetazole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase) and a reaction with ethanol similar to that produced by disulfiram, due to inhibition of aldehyde dehydrogenase.[1]
Spectrum of bacterial susceptibility
Cefmetazole is a broad-spectrum cephalosporin antimicrobial and has been effective in treating bacteria responsible for causing urinary tract and skin infections. [citation needed]The following represents MIC susceptibility data for a few medically significant microorganisms.
- Bacteroides fragilis: 0.06 - >256 µg/ml
- Clostridium difficile: 8 - >128 µg/ml
- Staphylococcus aureus: 0.5 - 256 µg/ml (includes MRSA)[2]
References
- ↑ "Antibiotics, antifungals, and antivirals". Goldfrank's toxicologic emergencies. New York: McGraw-Hill. 2006. pp. 847. ISBN 0-07-143763-0. https://books.google.com/books?id=cvJuLqBxGUcC&pg=PA847. Retrieved 2009-07-03.
- ↑ "Cefmetazole, free acid Susceptibility and Concentration Range (μg/ml) Minimum Inhibitory Concentration (MIC) Data". The Antimicrobial Index. TOKU-E. 6 January 2020. http://www.toku-e.com/Assets/MIC/Cefmetazole%20free%20acid.pdf.
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