gamma-MSH, γ-melanotropin, γ-melanocortin, γ-intermedin
|Molar mass||1570.77396 g/mol|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
γ-Melanocyte-stimulating hormone (γ-MSH) is an endogenous peptide hormone and neuropeptide. It is a melanocortin, specifically, one of the three types of melanocyte-stimulating hormone (MSH), and is produced from proopiomelanocortin (POMC). It is an agonist of the MC1, MC3, MC4, and MC5 receptors. It exists in three forms, γ1-MSH, γ2-MSH, and γ3-MSH.
Gamma-MSH regulated cardiovascular functions. Gama-MSH effects are measured through the effects it has on the central neural pathway dispersed throughout the kidney. It is not moderated based on tubular sodium transport. Gamma-MSH activates MC3R in renal tubular cells by limiting sodium absorption by inhibiting the central neural pathway.This regulates sodium balance and blood pressure. If MC3R is absent then there is resistance in γ-MSH which results in hypertension on HSD.
- α-Melanocyte-stimulating hormone
- β-Melanocyte-stimulating hormone
- Adrenocorticotropic hormone
- Handbook of Biologically Active Peptides. Academic Press. 26 January 2013. pp. 838–844. ISBN 978-0-12-385096-6. https://books.google.com/books?id=Xz4yFpdSRrwC&pg=PA838.
- Peptides from A to Z: A Concise Encyclopedia. John Wiley & Sons. 8 September 2008. pp. 216–. ISBN 978-3-527-62117-0. https://books.google.com/books?id=doe9NwgJTAsC&pg=PA216.
- "The natriuretic mechanism of Gamma-Melanocyte-Stimulating Hormone". Peptides 32 (5): 1068–1072. May 2011. doi:10.1016/j.peptides.2011.02.006. PMID 21335042.
- "Salt-sensitive hypertension: if only it were as simple as rocket science". The Journal of Clinical Investigation 111 (8): 1115–1116. April 2003. doi:10.1172/jci200316993. PMID 12697727.
Original source: https://en.wikipedia.org/wiki/Gamma-Melanocyte-stimulating hormone. Read more