Chemistry:Pelubiprofen
From HandWiki
Pelubiprofen is a nonsteroidal anti-inflammatory drug of the profen class used to treat back pain and osteoarthritis.[1]
Pelubiprofen was developed in South Korea by Daewon Pharmaceuticals and it is marketed in Korea and Russia,[2] among other countries.
Research
Pelubiprofen is being studied for use in combination with eperisone.[3]
Because pelubiprofen has low water solubility, development of salt formulations with better solubility are being studied.[4]
Synthesis
Pelubiprofen can be prepared by the reaction of 1-(1-piperidino)cyclohexene (1) with ethyl 2-(4-formylphenyl)propanoate (2).[5][6][7][8][9][10][11]
References
- ↑ "Pelubiprofen - Daewon Pharmaceutical". AdisInsight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800000947.
- ↑ "Daewon Pharm wins $3 million deal to export Pelubi to Indonesia". Korea Biomedial Review. 26 September 2023. https://www.koreabiomed.com/news/articleView.html?idxno=22165.
- ↑ "(Eperisone + pelubiprofen) by Daewon Pharmaceutical for Low Back Pain: Likelihood of Approval". 5 June 2023. https://www.pharmaceutical-technology.com/data-insights/pelubiprofen-sr-daewon-pharmaceutical-chronic-low-back-pain-clbp-likelihood-of-approval/?cf-view.
- ↑ "Development of Pelubiprofen Tromethamine with Improved Gastrointestinal Safety and Absorption". Pharmaceutics 13 (5): 745. May 2021. doi:10.3390/pharmaceutics13050745. PMID 34070062.
- ↑ Serradell, MN; Castaer, J.; RS-2131. Drugs Fut 1984, 9, 4, 275.
- ↑ Terada, Atsusuke; Naruto, Shunji; Wachi, Kazuyuki; Tanaka, Shigeru; Iizuka, Yoshio; Misaka, Eiichi (1984). "Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds". Journal of Medicinal Chemistry. 27 (2): 212–216. doi:10.1021/jm00368a019.
- ↑ Atsusuke Terada, Shigeru Tanaka, & Eiichi Misaka, US4254274 (1981 to Sankyo Co Ltd).
- ↑ Yuan Weiguan, et al. CN111153791 (2020 to HUNAN JIUDIAN HONGYANG PHARMACEUTICAL Co., Ltd).
- ↑ Yuan Weiguan, et al. WO2021129651 (to Hunan Jiudian Pharmaceutical Co Ltd).
- ↑ Ning Hulin, et al. CN110041191 (2019 to HUNAN JIUDIAN HONGYANG PHARMACEUTICAL Co., Ltd.).
- ↑ ChemDrug
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