Chemistry:Zardaverine
From HandWiki
Zardaverine is a dual-selective PDE3/4 phosphodiesterase inhibitor.[1] Studies in vitro suggest that it may have useful anti-cancer properties.[2]
References
- ↑ Kümmerle, AE; Schmitt, M; Cardozo, SV; Lugnier, C; Villa, P; Lopes, AB; Romeiro, NC; Justiniano, H et al. (2012). "Design, Synthesis, and Pharmacological Evaluation of N-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase-4 Inhibitors". Journal of Medicinal Chemistry 55 (17): 7525–45. doi:10.1021/jm300514y. PMID 22891752.
- ↑ Corsello, SM; Nagari, RT; Spangler, RD; Rossen, J; Kocak, M; Bryan, JG; Humeidi, R; Peck, D et al. (2020). "Discovering the anticancer potential of non-oncology drugs by systematic viability profiling". Nature Cancer 1 (2): 235–248. doi:10.1038/s43018-019-0018-6. PMID 32613204.
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