Chemistry:Zardaverine
From HandWiki
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| Preferred IUPAC name
6-[3-(Difluoromethoxy)-4-methoxyphenyl]pyridazin-3(2H)-one | |
| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C12H10F2N2O3 | |
| Molar mass | 268.220 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
Zardaverine is a dual-selective PDE3/4 phosphodiesterase inhibitor.[1] Studies in vitro suggest that it may have useful anti-cancer properties.[2]
References
- ↑ Kümmerle, AE; Schmitt, M; Cardozo, SV; Lugnier, C; Villa, P; Lopes, AB; Romeiro, NC; Justiniano, H et al. (2012). "Design, Synthesis, and Pharmacological Evaluation of N-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase-4 Inhibitors". Journal of Medicinal Chemistry 55 (17): 7525–45. doi:10.1021/jm300514y. PMID 22891752.
- ↑ Corsello SM, Nagari RT, Spangler RD, et al. Discovering the anticancer potential of non-oncology drugs by systematic viability profiling. Nature Cancer (2020). doi:10.1038/s43018-019-0018-6
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