Chemistry:MY-5445
From HandWiki
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| Preferred IUPAC name
N-(3-Chlorophenyl)-4-phenylphthalazin-1-amine | |
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3D model (JSmol)
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PubChem CID
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| Properties | |
| C20H14ClN3 | |
| Molar mass | 331.80 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Tracking categories (test):
MY-5445 is a relatively specific phosphodiesterase 5 inhibitor.[1][2]
See also
- Vatalanib — a structurally related angiogenesis inhibitor
References
- ↑ Nagendran, J; Archer, SL; Soliman, D; Gurtu, V; Moudgil, R; Haromy, A; St. Aubin, C; Webster, L et al. (17 July 2007). "Phosphodiesterase Type 5 is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility". Circulation 116 (3): 238–48. doi:10.1161/circulationaha.106.655266. PMID 17606845. http://circ.ahajournals.org/content/116/3/238.full.pdf.
- ↑ Hagiwara, M; Endo, T; Kanayama, T; Hidaka, H (February 1984). "Effect of 1-(3-Chloroanilino)-4-phenylphthalazine (MY-5445), a Specific Inhibitor of Cyclic GMP Phosphodiesterase, on Human Platelet Aggregation". The Journal of Pharmacology and Experimental Therapeutics 228 (2): 467–71. PMID 6141286.
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