Chemistry:Propentofylline
From HandWiki
Short description: Chemical compound
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| Formula | C15H22N4O3 |
| Molar mass | 306.366 g·mol−1 |
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Propentofylline (HWA 285) is a xanthine derivative drug with purported neuroprotective effects.
Pharmacology
It is a phosphodiesterase inhibitor,[1] and also acts as an adenosine reuptake inhibitor.[1][2][3]
Uses
Propentofylline was studied as a possible treatment for Alzheimer's disease and multi-infarct dementia,[1][4] and has been studied, to a lesser extent, as a possible adjunct in the treatment of ischemic stroke, due to its vasodilating properties.[5][6]
Propentofylline is in use as a veterinary medicine in older dogs.[7]
See also
External links
References
- ↑ 1.0 1.1 1.2 "Propentofylline for dementia". The Cochrane Database of Systematic Reviews (2): CD002853. 2003. doi:10.1002/14651858.CD002853. PMID 12804440.
- ↑ "A placebo controlled study of the propentofylline added to risperidone in chronic schizophrenia". Progress in Neuro-Psychopharmacology & Biological Psychiatry 32 (3): 726–732. April 2008. doi:10.1016/j.pnpbp.2007.11.021. PMID 18096287.
- ↑ "Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet". Neuroscience 84 (4): 1127–1133. June 1998. doi:10.1016/S0306-4522(97)00542-3. PMID 9578400.
- ↑ "Clinical trials in dementia with propentofylline". Annals of the New York Academy of Sciences 826 (1): 307–316. September 1997. doi:10.1111/j.1749-6632.1997.tb48481.x. PMID 9329701. Bibcode: 1997NYASA.826..307K.
- ↑ "Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke". The Cochrane Database of Systematic Reviews (3): CD000162. 2004. doi:10.1002/14651858.CD000162.pub2. PMID 15266424.
- ↑ "Effect of propentofylline on regional cerebral glucose metabolism in acute ischemic stroke". Journal of Cerebral Blood Flow and Metabolism 13 (3): 526–530. May 1993. doi:10.1038/jcbfm.1993.68. PMID 8478410.
- ↑ "Launch of tablet to make life easier for dogs in old age". Yorkshire Post. 7 September 2012. https://www.yorkshirepost.co.uk/news/launch-of-tablet-to-make-life-easier-for-dogs-in-old-age-1-4904441.
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