Chemistry:SCH-51866
From HandWiki
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| IUPAC name
(6aR,9aS)-5-Methyl-2-[4-(trifluoromethyl)benzyl]-5,6a,7,8,9,9a-hexahydrocyclopenta[4,5]imidazo[2,1-b]purin-4(3H)-one
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3D model (JSmol)
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PubChem CID
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| Properties | |
| C19H18F3N5O | |
| Molar mass | 389.382 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
SCH-51866 is a phosphodiesterase inhibitor.[1][2]
References
- ↑ Lusche, DF; Kaneko, H; Malchow, D (18 April 2005). "cGMP-Phosphodiesterase Antagonists Inhibit Ca2+-Influx in Dictyostelium discoideum and Bovine Cyclic-Nucleotide-Gated-Channel". European Journal of Pharmacology 513 (1–2): 9–20. doi:10.1016/j.ejphar.2005.01.047. PMID 15878705.
- ↑ Beaumont, V; Park, L; Rassoulpour, A; Dijkman, U; Heikkinen, T; Lehtimaki, K; Kontkanen, O; Al Nackkash, R et al. (13 February 2014). "The PDE1/5 Inhibitor SCH-51866 Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease". PLOS Currents 6. doi:10.1371/currents.hd.3304e87e460b4bb0dc519a29f4deccca. PMID 24558637.
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