Chemistry:HT-0712
 | |
| Clinical data | |
|---|---|
| Other names | HT-0712, IPL 455,903 |
| ATC code |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| Chemical and physical data | |
| Formula | C25H31NO3 |
| Molar mass | 393.527 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
HT-0712, also known as IPL-455903,[1] is an experimental cognitive enhancing drug (nootropic) which is currently undergoing clinical trials. It is currently being licensed by Helicon Therapeutics in San Diego, California. It was originally discovered and tested as part of a preclinical anti-inflammatory program by Inflazyme Pharmaceuticals.[2]
Mechanism of action
HT-0712 appears to act as a PDE4 inhibitor, thereby increasing cAMP levels. When cAMP levels are increased in neurons, this may trigger activation of cAMP response element-binding proteins (CREB). CREBs are transcription factors involved in the formation of long-term memory.[2]
The side effects of the drug are not yet fully known.
Research
A 2014 study found that HT-0712 significantly boosted memory formation in mice. Data also indicated that HT-0712 may be effective to treat age-associated memory impairment in humans.[3]
References
- ↑ "Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking?". British Journal of Pharmacology 155 (3): 288–290. October 2008. doi:10.1038/bjp.2008.297. PMID 18660832.
- ↑ 2.0 2.1 "A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia". Neurorehabilitation and Neural Repair 21 (6): 486–496. 2007. doi:10.1177/1545968307305521. PMID 17823313.
- ↑ "The PDE4 inhibitor HT-0712 improves hippocampus-dependent memory in aged mice". Neuropsychopharmacology 39 (13): 2938–2948. December 2014. doi:10.1038/npp.2014.154. PMID 24964813.
External links
 |  |
