Biology:mir-765 microRNA precursor family
| mir-765 | |
|---|---|
| Identifiers | |
| Symbol | mir-765 |
| Rfam | RF01027 |
| miRBase family | MIPF0000545 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
In molecular biology mir-765 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Traumatic Brain Injury
miR-765 has been identified as a diagnostic marker for traumatic brain injury (TBI), due to significantly elevated levels in the plasma of TBI patients. Furthermore, combination with either miR-16 or miR-92a allows extremely accurate distinction between TBI patients and healthy controls.[1]
miR-765 and pheochromocytomas
Increased miR-765 expression is observed in Von Hippel-Lindau disease compared with the sporadic benign forms of pheochromocytomas.[2] It has been linked to neuronal plasticity through the neurotrophic tyrosine kinase receptor type 3 (NTRK3) gene. A NTRK3 3'UTR variant, ss102661458, is located in a functional target site of miR-765 and is able to significantly affect miRNA-mediated NTRK3 regulation. Through this there is restoration of the altered gene expression by miR-765. NTRK3 is underexpressed with high or overexpressed levels of miR-765, thus pointing towards a possible involvement of this relationship in pheochromocytoma pathogenesis.[3]
See also
References
- ↑ "Human traumatic brain injury alters plasma microRNA levels.". J. Neurotrauma 27 (12): 2147–56. 2010. doi:10.1089/neu.2010.1481. PMID 20883153.
- ↑ "MicroRNA expression profiling in benign (sporadic and hereditary) and recurring adrenal pheochromocytomas.". Mod. Pathol. 23 (12): 1583–95. 2010. doi:10.1038/modpathol.2010.164. PMID 20818339.
- ↑ "Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders.". Hum. Mutat. 30 (7): 1062–71. 2009. doi:10.1002/humu.21005. PMID 19370765. https://pubmed.ncbi.nlm.nih.gov/19370765.
Further reading
- Gu, H.; Li, H.; Zhang, L.; Luan, H.; Huang, T.; Wang, L.; Fan, Y.; Zhang, Y. et al. (2012). "Diagnostic role of microRNA expression profile in the serum of pregnant women with fetuses with neural tube defects". Journal of Neurochemistry 122 (3): 641–649. doi:10.1111/j.1471-4159.2012.07812.x. PMID 22642222.
- Della Vittoria Scarpati, G.; Falcetta, F.; Carlomagno, C.; Ubezio, P.; Marchini, S.; De Stefano, A.; Singh, V. K.; d'Incalci, M. et al. (2011). "A Specific miRNA Signature Correlates with Complete Pathological Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer". International Journal of Radiation Oncology, Biology, Physics 83 (4): 1113–1119. doi:10.1016/j.ijrobp.2011.09.030. PMID 22172905.
- Guidi, M.; Muiños-Gimeno, M.; Kagerbauer, B.; Martí, E. L.; Estivill, X.; Espinosa-Parrilla, Y. (2010). "Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells". BMC Molecular Biology 11: 95. doi:10.1186/1471-2199-11-95. PMID 21143953.
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