Biology:mir-101 microRNA precursor family
From HandWiki
| mir-101 microRNA precursor family | |
|---|---|
 Predicted secondary structure and sequence conservation of mir-101 | |
| Identifiers | |
| Symbol | mir-101 |
| Rfam | RF00253 |
| miRBase | MI0000103 |
| miRBase family | MIPF0000046 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | 0035195 0035068 |
| SO | 0001244 |
| PDB structures | PDBe |
miR-101 microRNA precursor is a small non-coding RNA that regulates gene expression. Expression of miR-101 has been validated in both human (MI0000103, MI0000739)[1] and mouse (MI0000148).[2] This microRNA appears to be specific to the vertebrates and has now been predicted or confirmed in a wide range of vertebrate species (MIPF0000046). The precursor microRNA is a stem-loop structure of about 70 nucleotides in length that is processed by the Dicer enzyme to form the 21-24 nucleotide mature microRNA. In this case the mature sequence is excised from the 3' arm of the hairpin.
Survival analysis shows that hsa-miR-101 is associated with survival in multiple breast cancer datasets.[3]
References
- ↑ "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes & Development 16 (6): 720–8. March 2002. doi:10.1101/gad.974702. PMID 11914277.
- ↑ "Identification of tissue-specific microRNAs from mouse". Current Biology 12 (9): 735–9. April 2002. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
- ↑ "miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patients". Breast Cancer Research and Treatment 160 (3): 439–446. December 2016. doi:10.1007/s10549-016-4013-7. PMID 27744485.
Further reading
- "Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth". The FEBS Journal 279 (22): 4201–12. November 2012. doi:10.1111/febs.12013. PMID 23013439.
External links
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