Biology:PTPRZ1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene.[1][2][3]
Function
This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.[3]
Clinical significance
Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration.[3]
References
- ↑ "Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3". Cytogenetics and Cell Genetics 70 (1–2): 52–54. Jun 1995. doi:10.1159/000133990. PMID 7736789.
- ↑ "The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system". The Journal of Biological Chemistry 268 (14): 10573–10581. Jun 1993. doi:10.1016/S0021-9258(18)82237-2. PMID 8387522.
- ↑ 3.0 3.1 3.2 "Entrez Gene: PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=5803.
Further reading
- "A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases". Proceedings of the National Academy of Sciences of the United States of America 89 (16): 7417–7421. 1992. doi:10.1073/pnas.89.16.7417. PMID 1323835. Bibcode: 1992PNAS...89.7417K.
- "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proceedings of the National Academy of Sciences of the United States of America 87 (18): 7000–7004. 1990. doi:10.1073/pnas.87.18.7000. PMID 2169617. Bibcode: 1990PNAS...87.7000K.
- "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases". The EMBO Journal 9 (10): 3241–3252. 1990. doi:10.1002/j.1460-2075.1990.tb07523.x. PMID 2170109.
- "Subregional localization of 21 chromosome 7-specific expressed sequence tags (ESTs) by FISH using newly identified YACs and P1s". Genomics 46 (3): 491–494. 1998. doi:10.1006/geno.1997.5051. PMID 9441757.
- "Molecular cloning and expression analysis of five novel genes in chromosome 1p36". Genomics 50 (2): 187–198. 1998. doi:10.1006/geno.1997.5186. PMID 9653645.
- "Toward a complete human genome sequence". Genome Research 8 (11): 1097–1108. November 1998. doi:10.1101/gr.8.11.1097. PMID 9847074.
- "A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta". The Journal of Biological Chemistry 274 (18): 12474–12479. 1999. doi:10.1074/jbc.274.18.12474. PMID 10212223.
- "Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family". Brain Research. Molecular Brain Research 72 (1): 47–54. 1999. doi:10.1016/S0169-328X(99)00204-1. PMID 10521598.
- "Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta". Proceedings of the National Academy of Sciences of the United States of America 97 (6): 2603–2608. 2000. doi:10.1073/pnas.020487997. PMID 10706604. Bibcode: 2000PNAS...97.2603M.
- "Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system". Proceedings of the National Academy of Sciences of the United States of America 98 (12): 6593–6598. 2001. doi:10.1073/pnas.041608698. PMID 11381105. Bibcode: 2001PNAS...98.6593K.
- "Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells". Journal of Neurochemistry 78 (4): 767–778. 2001. doi:10.1046/j.1471-4159.2001.00454.x. PMID 11520897.
- "A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions". Nature Genetics 32 (3): 411–414. 2002. doi:10.1038/ng1004. PMID 12355066.
- "A role for receptor tyrosine phosphatase zeta in glioma cell migration". Oncogene 22 (43): 6661–6668. 2003. doi:10.1038/sj.onc.1206763. PMID 14555979.
- "Mutation screening and association analysis of six candidate genes for autism on chromosome 7q". European Journal of Human Genetics 13 (2): 198–207. 2005. doi:10.1038/sj.ejhg.5201315. PMID 15523497.
- "Characterization of heparin affin regulatory peptide signaling in human endothelial cells". The Journal of Biological Chemistry 280 (23): 22454–22461. 2005. doi:10.1074/jbc.M414407200. PMID 15797857.
- "Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells". Cancer Research 65 (8): 3299–3306. 2005. doi:10.1158/0008-5472.CAN-04-4130. PMID 15833863.
- "Differential induction of glioblastoma migration and growth by two forms of pleiotrophin". The Journal of Biological Chemistry 280 (29): 26953–26964. 2005. doi:10.1074/jbc.M502614200. PMID 15908427.
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