Biology:VEGFR1
 Generic protein structure example |
Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.[1]
Function
FLT1 is a member of VEGF receptor gene family. It encodes a receptor tyrosine kinase which is activated by VEGF-A, VEGF-B, and placental growth factor. The sequence structure of the FLT1 gene resembles that of the FMS (now CSF1R) gene; hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[2]
The ablation of VEGFR1 by chemical and genetic means has also recently been found to augment the conversion of white adipose tissue to brown adipose tissue as well as increase brown adipose angiogenesis in mice.[3]
Functional genetic variation in FLT1 (rs9582036) has been found to affect non-small cell lung cancer survival.[4]
Interactions
FLT1 has been shown to interact with PLCG1[5] and vascular endothelial growth factor B (VEGF-B).[6][7]
See also
- VEGF receptors
References
- ↑ "Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family". Oncogene 5 (4): 519–24. April 1990. PMID 2158038.
- ↑ "FLT1 fms related receptor tyrosine kinase 1 [ Homo sapiens (human) "]. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2321.
- ↑ "Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning". The Journal of Experimental Medicine 215 (2): 611–626. February 2018. doi:10.1084/jem.20171012. PMID 29305395.
- ↑ "Functional FLT1 Genetic Variation is a Prognostic Factor for Recurrence in Stage I-III Non-Small-Cell Lung Cancer". Journal of Thoracic Oncology 10 (7): 1067–75. July 2015. doi:10.1097/JTO.0000000000000549. PMID 26134224.
- ↑ "Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites". Biochemical and Biophysical Research Communications 240 (3): 635–9. November 1997. doi:10.1006/bbrc.1997.7719. PMID 9398617.
- ↑ "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells". Proceedings of the National Academy of Sciences of the United States of America 95 (20): 11709–14. September 1998. doi:10.1073/pnas.95.20.11709. PMID 9751730.
- ↑ "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". The Journal of Biological Chemistry 274 (30): 21217–22. July 1999. doi:10.1074/jbc.274.30.21217. PMID 10409677.
Further reading
- "Signaling via vascular endothelial growth factor receptors". Experimental Cell Research 253 (1): 117–30. November 1999. doi:10.1006/excr.1999.4707. PMID 10579917.
- "Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction". Annals of the New York Academy of Sciences 902 (1): 201–5; discussion 205–7. May 2000. doi:10.1111/j.1749-6632.2000.tb06314.x. PMID 10865839.
- "Signals from Eph and ephrin proteins: a developmental tool kit". Science's STKE 2001 (112): re20. December 2001. doi:10.1126/stke.2001.112.re20. PMID 11741094.
- "Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders". Annals of the New York Academy of Sciences 979: 80–93. December 2002. doi:10.1111/j.1749-6632.2002.tb04870.x. PMID 12543719.
- "Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia". Pediatric Research 57 (5 Pt 2): 1R–7R. May 2005. doi:10.1203/01.PDR.0000159567.85157.B7. PMID 15817508.
- "Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis". Angiogenesis 9 (4): 225–30; discussion 231. 2007. doi:10.1007/s10456-006-9055-8. PMID 17109193.
- "Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review". Obstetrics and Gynecology 109 (1): 168–80. January 2007. doi:10.1097/01.AOG.0000249609.04831.7c. PMID 17197602.
- "Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia". Nephrology, Dialysis, Transplantation 22 (3): 712–4. March 2007. doi:10.1093/ndt/gfl768. PMID 17210583.
- "Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration". The Journal of Neuroscience 28 (42): 10451–9. October 2008. doi:10.1523/JNEUROSCI.1092-08.2008. PMID 18923022.
- "Vascular endothelial growth factors VEGF-B and VEGF-C". Journal of Cellular Physiology 173 (2): 211–5. November 1997. doi:10.1002/(SICI)1097-4652(199711)173:2<211::AID-JCP23>3.0.CO;2-H. PMID 9365524.
- "VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche". Nature 438 (7069): 820–7. December 2005. doi:10.1038/nature04186. PMID 16341007. Bibcode: 2005Natur.438..820K.
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