Chemistry:GSK417651A

GSK417651A
Identifiers
	IUPAC name 3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone;
CAS Number	736945-96-3 ;
PubChem CID	1096735;
UNII	WV82DEG4YA;
Chemical and physical data
Formula	C20H19N3O2S
Molar mass	365.45 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC=C(C=C1)NC2=NC(=CS2)C(=O)N3CCC4=CC=CC=C4C3;
	InChI InChI=1S/C20H19N3O2S/c1-25-17-8-6-16(7-9-17)21-20-22-18(13-26-20)19(24)23-11-10-14-4-2-3-5-15(14)12-23/h2-9,13H,10-12H2,1H3,(H,21,22); Key:NTXBDULODNTCKP-UHFFFAOYSA-N;

Short description: Chemical compound

GSK417651A is a chemical compound which acts as a blocker of the TRPC family of calcium channels, with selectivity for the TRPC3 and TRPC6 subtypes. It has been used to investigate the role of TRPC3/6 channels in heart function.^[1]^[2]^[3]

References

↑ "CG Characterization of Small Molecule TRPC3 and TRPC6 agonist and Antagonists.". Biophysical Journal 104 (2): 454a. 2013. doi:10.1016/j.bpj.2012.11.2513. Bibcode: 2013BpJ...104..454X.
↑ "Role of Transient Receptor Potential Canonical Channels in Heart Physiology and Pathophysiology". Frontiers in Cardiovascular Medicine 7: 24. 2020. doi:10.3389/fcvm.2020.00024. PMID 32158769.
↑ "Expression and function of mechanosensitive ion channels in human valve interstitial cells". PLOS ONE 15 (10): e0240532. 2020. doi:10.1371/journal.pone.0240532. PMID 33057457. Bibcode: 2020PLoSO..1540532A.

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[1] "CG Characterization of Small Molecule TRPC3 and TRPC6 agonist and Antagonists.". Biophysical Journal 104 (2): 454a. 2013. doi:10.1016/j.bpj.2012.11.2513. Bibcode: 2013BpJ...104..454X.

[2] "Role of Transient Receptor Potential Canonical Channels in Heart Physiology and Pathophysiology". Frontiers in Cardiovascular Medicine 7: 24. 2020. doi:10.3389/fcvm.2020.00024. PMID 32158769.

[3] "Expression and function of mechanosensitive ion channels in human valve interstitial cells". PLOS ONE 15 (10): e0240532. 2020. doi:10.1371/journal.pone.0240532. PMID 33057457. Bibcode: 2020PLoSO..1540532A.

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Identifiers

IUPAC name 3,4-dihydro-1H-isoquinolin-2-yl-[2-(4-methoxyanilino)-1,3-thiazol-4-yl]methanone
CAS Number	736945-96-3^Y
PubChem CID	1096735
UNII	WV82DEG4YA
Chemical and physical data
Formula	C₂₀H₁₉N₃O₂S
Molar mass	365.45 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COC1=CC=C(C=C1)NC2=NC(=CS2)C(=O)N3CCC4=CC=CC=C4C3
InChI InChI=1S/C20H19N3O2S/c1-25-17-8-6-16(7-9-17)21-20-22-18(13-26-20)19(24)23-11-10-14-4-2-3-5-15(14)12-23/h2-9,13H,10-12H2,1H3,(H,21,22) Key:NTXBDULODNTCKP-UHFFFAOYSA-N

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