Chemistry:SB-705498
From HandWiki
Short description: Chemical compound
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| Formula | C17H16BrF3N4O |
| Molar mass | 429.241 g·mol−1 |
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SB-705498 is a drug which acts as a potent and selective blocker of the TRPV1 ion channel.[1][2] It has been evaluated in clinical trials for the treatment of rhinitis and chronic cough.[3][4][5]
See also
References
- ↑ "Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development". Bioorganic & Medicinal Chemistry Letters 16 (12): 3287–91. June 2006. doi:10.1016/j.bmcl.2006.03.030. PMID 16580202.
- ↑ "Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor". The Journal of Pharmacology and Experimental Therapeutics 321 (3): 1183–92. June 2007. doi:10.1124/jpet.106.116657. PMID 17392405.
- ↑ "Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks". Brain Research Reviews 60 (1): 267–77. April 2009. doi:10.1016/j.brainresrev.2008.12.006. PMID 19150372.
- ↑ "The effects of a TRPV1 antagonist, SB-705498, in the treatment of seasonal allergic rhinitis". International Journal of Clinical Pharmacology and Therapeutics 51 (7): 576–84. July 2013. doi:10.5414/CP201890. PMID 23735181.
- ↑ "Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist". British Journal of Clinical Pharmacology 77 (5): 777–88. May 2014. doi:10.1111/bcp.12219. PMID 23909699.
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