Chemistry:HC-067047
From HandWiki
Short description: Chemical compound
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| Formula | C26H28F3N3O2 |
| Molar mass | 471.524 g·mol−1 |
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HC-067047 is a drug which acts as a potent and selective antagonist for the TRPV4 receptor. It has been used to investigate the role of TRPV4 receptors in a number of areas, such as regulation of blood pressure, bladder function and some forms of pain, as well as neurological functions.[1][2][3][4][5][6][7]
See also
References
- ↑ "Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis". Proceedings of the National Academy of Sciences of the United States of America 107 (44): 19084–9. November 2010. doi:10.1073/pnas.1005333107. PMID 20956320. Bibcode: 2010PNAS..10719084E.
- ↑ "Transient receptor potential vanilloid 4 mediates hypotonicity-induced enhancement of synaptic transmission in hippocampal slices". CNS Neuroscience & Therapeutics 19 (11): 854–62. November 2013. doi:10.1111/cns.12143. PMID 23826708.
- ↑ "Endothelial TRPV4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer's disease". British Journal of Pharmacology 170 (3): 661–70. October 2013. doi:10.1111/bph.12315. PMID 23889563.
- ↑ "TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor". Pain 155 (12): 2662–72. December 2014. doi:10.1016/j.pain.2014.09.033. PMID 25281928.
- ↑ "Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways". Cell Death & Disease 6 (6): e1775. June 2015. doi:10.1038/cddis.2015.146. PMID 26043075.
- ↑ "The selective TRPV4 channel antagonist HC-067047 attenuates mechanical allodynia in diabetic mice". European Journal of Pharmacology 856: 172408. August 2019. doi:10.1016/j.ejphar.2019.172408. PMID 31129158.
- ↑ "Therapeutic potential of pharmacological agents targeting TRP channels in CNS disorders". Pharmacological Research 159: 105026. September 2020. doi:10.1016/j.phrs.2020.105026. PMID 32562815.
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