Biology:TRPM
From HandWiki
Short description: Family of transport proteins
TRPM is a family of transient receptor potential ion channels (M standing for wikt:melastatin).[1] Functional TRPM channels are believed to form tetramers.[2] The TRPM family consists of eight different channels, TRPM1–TRPM8.[3]
Unlike the TRPC and TRPV sub-families, TRPM subunits do not contain N-terminal ankyrin repeat motifs but, rather, contain entire functional proteins in their C-termini. TRPM6 and TRPM7, for example, contain functional α-kinase segments, which are a type of serine/threonine-specific protein kinase.
Permeability and activation
The relative permeability of calcium and magnesium varies widely among TRPM channels.
- TRPM4 and TRPM5 are impermeable to calcium.
- TRPM3, TRPM6 and TRPM7 are highly permeable to both calcium and magnesium.
The mechanism of activation also varies greatly among TRPM channels.
- TRPM2 is activated by ADP-ribose adenosine 5'-diphosphoribose and functions as a sensor of redox status in cells.[4]
- TRPM4 and TRPM5 are activated by intracellular calcium.
- TRPM8 can be activated by low temperatures, menthol, eucalyptol and icilin.[5][6]
Functions
Among the functional responsibilities of the TRPM channels are:
- regulation of calcium oscillations after T cell activation[7] and prevention of cardiac conduction disorders (TRPM4).[8]
- modulation of insulin secretion and sensory transduction in taste cells (TRPM5).[9]
- cold sensation (TRPM8).
- heat sensation and inflammatory pain (TRPM3).[10]
- regulation of magnesium reabsorption in the kidneys and absorption in the intestines (TRPM6).[11]
- regulation of cell adhesion (TRPM7).[12]
Genes
References
- ↑ "The mammalian melastatin-related transient receptor potential cation channels: an overview". Pflügers Arch 451 (1): 204–211. 2005. doi:10.1007/s00424-005-1428-0. PMID 15895246.
- ↑ Jiang LH (2007). "Subunit interaction in channel assembly and functional regulation of transient receptor potential melastatin (TRPM) channels". Biochem Soc Trans 35 (1): 86–8. doi:10.1042/BST0350086. PMID 17233608.
- ↑ "TRP channels in neurogastroenterology: opportunities for therapeutic intervention". British Journal of Pharmacology 162 (1): 18–37. 2011. doi:10.1111/j.1476-5381.2010.01009.x. PMID 20804496.
- ↑ "LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death". Mol Cell 9 (1): 163–173. 2002. doi:10.1016/S1097-2765(01)00438-5. PMID 11804595.
- ↑ "Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay". Br. J. Pharmacol. 141 (4): 737–745. 2004. doi:10.1038/sj.bjp.0705652. PMID 14757700.
- ↑ "Transient receptor potential cation channels in disease". Physiol. Rev. 87 (1): 165–217. 2007. doi:10.1152/physrev.00021.2006. PMID 17237345. https://lirias.kuleuven.be/bitstream/123456789/137085/2/Nilius_Physiol+Reviews+TRP_Disease.pdf.
- ↑ "TRPM4 regulates calcium oscillations after T cell activation". Science 306 (5700): 1374–1377. 2004. doi:10.1126/science.1098845. PMID 15550671.
- ↑ Mathar, I; Jacobs, G; Kecskes, M; Menigoz, A; Philippaert, K; Vennekens, R (2014). TRPM4.. Handbook of Experimental Pharmacology. 222. pp. 461–87. doi:10.1007/978-3-642-54215-2_18. ISBN 978-3-642-54214-5.
- ↑ Philippaert, K; Pironet, A; Mesuere, M; Sones, W; Vermeiren, L; Kerselaers, S; Pinto, S; Segal, A et al. (31 March 2017). "Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity.". Nature Communications 8: 14733. doi:10.1038/ncomms14733. PMID 28361903.
- ↑ Held, K; Voets, T; Vriens, J (2014). "TRPM3 in temperature sensing and beyond.". Temperature (Austin, Tex.) 2 (2): 201–13. doi:10.4161/23328940.2014.988524. PMID 27227024.
- ↑ "Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family". Nat. Genet. 31 (2): 166–170. 2002. doi:10.1038/ng889. PMID 12032568.
- ↑ "TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain". J. Biol. Chem. 281 (16): 11260–11270. 2006. doi:10.1074/jbc.M512885200. PMID 16436382.
External links
- TRPM+Cation+Channels at the US National Library of Medicine Medical Subject Headings (MeSH)
- "Transient Receptor Potential Channels". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/IC/FamilyMenuForward?familyId=12.
- "TRIP Database". a manually curated database of protein-protein interactions for mammalian TRP channels. http://www.trpchannel.org.
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