Chemistry:Luzindole
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Short description: Chemical compound
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| Formula | C19H20N2O |
| Molar mass | 292.382 g·mol−1 |
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Luzindole (N-0774), (N-acetyl-2-benzyltryptamine), is a drug used in scientific research to study the role of melatonin in the body. Luzindole acts as a selective melatonin receptor antagonist,[1] with approximately 11- to 25-fold greater affinity for the MT2 over the MT1 receptor.[2][3] In animal studies, it has been observed to disrupt the circadian rhythm as well as produce antidepressant effects.[2][4]
References
- ↑ Dubocovich ML (September 1988). "Luzindole (N-0774): a novel melatonin receptor antagonist". The Journal of Pharmacology and Experimental Therapeutics 246 (3): 902–10. PMID 2843633. http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=2843633.
- ↑ 2.0 2.1 "Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms". The FASEB Journal 12 (12): 1211–20. September 1998. doi:10.1096/fasebj.12.12.1211. PMID 9737724. http://www.fasebj.org/cgi/pmidlookup?view=long&pmid=9737724.
- ↑ "Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors". British Journal of Pharmacology 129 (5): 877–86. March 2000. doi:10.1038/sj.bjp.0703130. PMID 10696085.
- ↑ "Antidepressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in the mouse behavioral despair test". European Journal of Pharmacology 182 (2): 313–25. July 1990. doi:10.1016/0014-2999(90)90290-M. PMID 2168835.
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