Chemistry:AL-37350A

From HandWiki

AL-37350A, also known as 4,5-dihydropyrano-α-methyltryptamine (4,5-DHP-AMT), is a serotonin receptor agonist and tricyclic tryptamine derivative related to the psychedelic tryptamine 5-MeO-AMT.[1][2] It acts as a potent and selective agonist for the serotonin receptor 5-HT2A, with a Ki of 2.0 nM, and moderate selectivity over the related 5-HT2B and 5-HT2C receptors.[1][2] The drug has been shown to have ocular hypotensive activity in animal models, suggesting it may be useful for the treatment of glaucoma.[2] AL-37350A was first described in the scientific literature by Jesse May and colleagues in 2003.[1][2]

See also

References

  1. ↑ 1.0 1.1 1.2 "Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and Non-Hallucinogenic Analogues as Emerging Antidepressants". Chem Rev 124 (1): 124–163. January 2024. doi:10.1021/acs.chemrev.3c00375. PMID 38033123. "In 2003, May et al. reported compound 47, which displayed potent agonist activity at the r5-HT2AR (EC50 = 28.6 nM, Emax = 103% vs 100% of 5-HT) in the Ca2+ mobilization assays, and a very strong binding affinity at the r5-HT2AR (Ki = 0.2 nM, [ 125I]-DOI) as well as good selectivity against other rat 5-HT receptors.149". 
  2. ↑ 2.0 2.1 2.2 2.3 "A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole". Journal of Medicinal Chemistry 46 (19): 4188–4195. September 2003. doi:10.1021/jm030205t. PMID 12954071. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:AL-37350A&oldid=4358904"