Chemistry:6-Fluoro-AMT

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6-Fluoro-AMT, or 6-fluoro-αMT, also known as 6-fluoro-α-methyltryptamine, is a psychedelic drug of the tryptamine family related to α-methyltryptamine (AMT) and 5-MeO-AMT.[1][2]

Use and effects

6-Fluoro-AMT was allegedly manufactured and sold from the laboratory operated by Leonard Pickard and Gordon Todd Skinner, who described 6-fluoro-AMT as "a beast".[1] In interviews, Skinner stated that he first began to experiment with 6-fluoro-AMT in the early 1980s by giving it to high school friends.[2] Their experiences made him cautious about the appropriate doses, which he said ranged from 25 to 75 mg (Skinner weighed about 250 lbs at the time of his own bioassay).[2] Skinner said that 6-fluoro-AMT is a long-lasting psychedelic with more time distortion and that it was enhanced by combination with ALD-52.[2]

Interactions

Pharmacology

Pharmacodynamics

Animal tests showed the drug to be somewhat less potent in terms of pharmacological activity than AMT or 5-fluoro-AMT.[3] It produces the head-twitch response, a behavioral proxy of psychedelic-like effects, in rodents.[4][5][6] Its IC50 for monoamine oxidase A (MAO-A) inhibition is 580 to 1,800 nM, compared to 180 to 450 nM for 5-fluoro-AMT and 380 nM for AMT.[5][7][8]

Chemistry

Analogues

Analogues of 6-fluoro-AMT include α-methyltryptamine (AMT), 5-fluoro-AMT, 5-chloro-AMT, 5-fluoro-AET, 5-chloro-AET, 6-fluoro-DMT, 6-fluoro-DET, 6-methyl-DMT, 6-MeO-DMT, 6-hydroxy-DMT, 7-chloro-AMT, and O-4310 (1-isopropyl-6-fluoro-4-HO-DMT), among others.

History

6-Fluoro-AMT was first described in the scientific literature, by Asher Kalir and Stephen Szara, by at least 1963.[3]

Society and culture

Canada

6-Fluoro-AMT is not an explicitly nor implicitly controlled substance in Canada as of 2025.[9]

United States

6-Fluoro-AMT is not an explicitly controlled substance in the United States.[10] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.

See also

  • Substituted α-alkyltryptamine

References

  1. ↑ 1.0 1.1 Morris, Hamilton (2010). "Life is a Cosmic Giggle on the Breath of the Universe. A Tour of Gordon Todd Skinner's Subterranean LSD Palace.". Vice Magazine. https://www.vice.com/en/article/getting-high-on-krystle-trailer/. 
  2. ↑ 2.0 2.1 2.2 2.3 "Unusual Analogues: Drugs Used by Gordon Todd Skinner". This Land Press. http://thislandpress.com/2013/07/25/unusual-analogues-drugs-used-by-gordon-todd-skinner/. 
  3. ↑ 3.0 3.1 "Synthesis and Pharmacological Activity of Fluorinated Tryptamine Derivatives". Journal of Medicinal Chemistry 6 (6): 716–719. November 1963. doi:10.1021/jm00342a019. PMID 14184932. 
  4. ↑ "Effect of Hallucinogens on Unconditioned Behavior". Behavioral Neurobiology of Psychedelic Drugs. Current Topics in Behavioral Neurosciences. 36. 2018. pp. 159–199. doi:10.1007/7854_2016_466. ISBN 978-3-662-55878-2. 
  5. ↑ 5.0 5.1 "Monoamine oxidase and head-twitch response in mice. Mechanisms of alpha-methylated substrate derivatives". Neurotoxicology 25 (1–2): 223–232. January 2004. doi:10.1016/S0161-813X(03)00101-3. PMID 14697897. Bibcode: 2004NeuTx..25..223N. 
  6. ↑ "alpha-Methylated tryptamine derivatives induce a 5-HT receptor-mediated head-twitch response in mice". Neuropharmacology 34 (2): 229–234. February 1995. doi:10.1016/0028-3908(94)00119-d. PMID 7617148. 
  7. ↑ "In vitro monoamine oxidase inhibition potential of alpha-methyltryptamine analog new psychoactive substances for assessing possible toxic risks". Toxicol Lett 272: 84–93. April 2017. doi:10.1016/j.toxlet.2017.03.007. PMID 28302559. https://researchonline.ljmu.ac.uk/id/eprint/5909/1/TOXLET-D-17-00086R1_accepted_uncorected.pdf. 
  8. ↑ Matthew Baggott, "Advantageous tryptamine compositions for mental disorders or enhancement", WO patent 2022061242, published 2023 March 24, assigned to Tactogen
  9. ↑ "Controlled Drugs and Substances Act". 5 December 2025. https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 
  10. ↑ Orange Book: List of Controlled Substances and Regulated Chemicals (January 2026), United States: U.S. Department of Justice: Drug Enforcement Administration (DEA): Diversion Control Division, January 2026, https://www.deadiversion.usdoj.gov/schedules/orangebook/orangebook.pdf 



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